Genital human papillomavirus screening by gene chip in Chinese women of Guangdong province
Abstract
Background Human papillomavirus (HPV) infections are associated with cervical cancer. There were only a few reports and detailed data about epidemiological research of HPV infection in general population of China. Aims To determine the prevalence of genital HPV infection in Chinese women of Guangdong province. Methods A total of 1705 women were screened by gene chip. All HPV-positive women were further examined by ThinPrep liquid-based cytology test (TCT), and the cervical biopsies of those women with positive HPV-DNA and abnormal TCT were collected for pathological diagnosis. Results The overall HPV prevalence was 9.03% (154 of 1705), and 72.3% (126 of 154) of total positive samples were high-risk types, with higher prevalence of types 52, 58, 16, 18 and CP8304. For women aged 51 years or older, the overall high-risk HPV prevalence was 12.2% (24 of 179), which was obviously higher than those of other age groups (P Conclusions Our results showed that the HPV prevalence in Guangdong is very similar to the world level. Unlike most previous studies, our findings suggest that HPV prevalence increased with age, and that the predominant genotypes in this area were HPV 52 and 58.
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The increase in HPV infection and multiple types with age is explained by cumulative lifetime exposure, relative incompetency in viral clearance, and insufficient adaptive immune responses at menopausal transition, contributing to HPV persistence or reactivation.
“The frequency of HPV infection and multiple types increases with age explains cumulative lifetime exposure [33], relative incompetency in viral clearance and insufficient adaptive immune responses at this age caused by hormonal changes at menopausal transition, contributing to HPV persistence or reactivation of latent HPV infections [34, 35].”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [33]
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Senapati, R., Nayak, B., Kar, S. K., & Dwibedi, B. (2017) · BMC Infectious Diseases · doi:10.1186/s12879-016-2136-4 · Cited by 95 · see citing works
“The frequency of HPV infection and multiple types increases with age explains cumulative lifetime exposure [33], relative incompetency in viral clearance and insufficient adaptive immune responses at this age caused by hormonal changes at menopausal transition, contributing to HPV persistence or reactivation of latent…”
Background
- Authors
- LIN, M., YANG, L., LI, L., WU, J., PENG, Y., & LUO, Z.
- Affiliations
- Chaozhou Central Hospital (CN)
- Corresponding author
- YANG, Li‐Ye
- ORCID
- Venue
- Australian and New Zealand Journal of Obstetrics and Gynaecology
- Publisher
- Wiley
- Published
- 2008-03-26
- Volume
- 48
- Issue
- 2
- Pages
- 189-194
- ISSN
- 0004-8666 (ISSN-L)
- 1479-828X
- OpenAlex
- W2118968091
- Cited by
- 32
- References
- 0
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 2 · 2020: 3 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 5
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Australian and New Zealand Journal of Obstetrics and Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Keywords
- human papillomavirus, genital HPV infection, HPV prevalence, high-risk HPV genotypes, HPV52, HPV58, HPV16, HPV 18, age-related prevalence, cervical cancer
- MeSH terms
- Adult, Aged, Carcinoma, Uterine Cervical Neoplasms, China, Female, Humans, Middle Aged, Prevalence, Age Distribution, Oligonucleotide Array Sequence Analysis, Papillomaviridae, Papillomavirus Infections
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