The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Disulfiram Treatment for Alcoholism in Severe Mental Illness
Abstract
Controlled research has shown that supervised disulfiram is an effective treatment for alcoholism. Despite this, little is known about the effects of disulfiram in persons with alcoholism and severe mental illness. We conducted comprehensive chart reviews on 33 patients with alcoholism and severe mental illness (70% schizophrenia or schizoaffective disorder) who had been prescribed disulfiram. Twenty‐one percent reported side effects from disulfiram, whereas significant psychiatric complications were not reported. Although 76%% of patients reported drinking while on disulfiram, only 28%o experienced negative reactions to alcohol. Sixty‐four percent of the patients saw a remission of alcoholism for at least one year during a three‐year follow‐up, and 30%o experienced a two‐year remission. Disulfiram treatment was associated with decreases in days hospitalized but not with changes in work status. The results suggest disulfiram may be a useful adjunctive treatment for alcoholism in patients with severe mental illness and that controlled research is needed to evaluate its effects in this population.
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“Agents for primary alcohol use disorder may also show benefits in BD, such as disulfiram (level 3),688, 689, 690, 691 naltrexone (level 3)692, 693, 694, 695 and gabapentin (level 4).696, 697”
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Self-citationPrevalence of Substance Abuse in Schizophrenia: Demographic and Clinical Correlates
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Self-citationDisulfiram treatment of alcoholism. A Veterans Administration cooperative study
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Self-citationAlcohol Use and Abuse in Schizophrenia
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Research works printed but not linked: 2
- Mueser KT, 1996, Dual Diagnosis of Major Mental Illness and Substance Abuse Disorder II: Recent Research and Clinical Implications. New Directions in Mental Health Services, Vol. 70, 33
- Mueser KT, 1995, Toolkit for Evaluating Substance Abuse in Persons with Severe Mental Illness
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Yatham, L. N., Kennedy, S. H., Parikh, S. V., Schaffer, A., Bond, D. J., Frey, B. N., Sharma, V., Goldstein, B. I., Rej, S., Beaulieu, S., et al. (2018) · Bipolar Disorders · doi:10.1111/bdi.12609 · Cited by 1,852
Integrated treatment of substance use and psychiatric disorders
Kelly, T. M., & Daley, D. C. (2013) · Social Work in Public Health · doi:10.1080/19371918.2013.774673 · Cited by 378
Lingford-Hughes, A., Welch, S., Peters, L., Nutt, D., & With expert reviewers (in alphabetical order): Ball D, B. N. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112444324 · Cited by 332
Naltrexone and disulfiram in patients with alcohol dependence and comorbid psychiatric disorders
Petrakis, I. L., Poling, J., Levinson, C., Nich, C., Carroll, K., & Rounsaville, B. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.016 · Cited by 177
Naltrexone and Disulfiram in Patients With Alcohol Dependence and Current Depression
Petrakis, I., Ralevski, E., Nich, C., Levinson, C., Carroll, K., Poling, J., & Rounsaville, B. (2007) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b13e3180337fcb · Cited by 66
Beaulieu, S., Saury, S., Sareen, J., Tremblay, J., Schütz, C. G., McIntyre, R. S., & Schaffer, A. (2012) · Annals of Clinical Psychiatry · doi:10.1177/104012371202400105 · Cited by 38
Fortuna, K. L., Lebby, S., Geiger, P., Johnson, D., MacDonald, S., Chefetz, I., Ferron, J. C., St George, L., Rossom, R., Kalisa, J., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.15479 · Cited by 18
Metadata
- Authors
- Mueser, K. T., Noordsy, D. L., Fox, L., & Wolfe, R.
- Affiliations
- Dartmouth College (US)
- Dartmouth Psychiatric Research Center (US)
- Corresponding author
- Mueser, Kim T.
- Venue
- The American Journal on Addictions
- Publisher
- Wiley
- Published
- 2003-05-06
- Volume
- 12
- Issue
- 3
- Pages
- 242-252
- ISSN
- 1055-0496 (ISSN-L)
- 1521-0391
- OpenAlex
- W2065550384
- Cited by
- 80
- References
- 30
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2019: 6 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 5 · 2013: 2 · 2012: 3
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal on Addictions (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (10265)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- disulfiram, alcoholism, severe mental illness, schizophrenia, schizoaffective disorder, alcoholism treatment, psychiatric complications, adverse effects, hospitalization, employment status, adjunctive therapy
- MeSH terms
- Absenteeism, Adult, Alcohol Deterrents, Alcoholism, Disulfiram, Female, Hospitalization, Humans, Male, Middle Aged, Psychotic Disorders, Retrospective Studies, Schizophrenia, Severity of Illness Index, Treatment Outcome
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