Long-term effects of acute ischemia and reperfusion injury
Open accessAbstract
Ischemia reperfusion (I/R) injury plays a major role in delayed graft function and long-term changes after kidney transplantation. By using different therapeutic strategies to prevent I/R injury in rat models of kidney transplantation we studied relationships between inflammatory cell arrival and adhesion molecule expression. In other rat models for acute renal failure we investigated the effect of up-regulation of protective genes such as heme oxygenase-1 (HO-1) on infiltrating cells, showing that infiltrating cells also contribute to beneficial effects. In order to gain more insight into the complex mechanisms of long-term changes after kidney transplantation, we started a protocol biopsy program to study histologic changes 6, 12, and 26 weeks after transplantation. The following article clarifies some of the complex mechanisms contributing to long-term changes caused by I/R injury.
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Exogenously administered NGAL markedly upregulates heme oxygenase-1, a protective agent in experimental acute kidney injury.
“Exogenously administered NGAL also markedly upregulates heme oxygenase-1, a proven multifunctional protective agent in experimental Acute Kidney Injury (AKI) that is thought to work by limiting iron uptake, promoting intracellular iron release, enhancing production of antioxidants such as biliverdin and carbon monoxide, and inducing the cell cycle regulatory protein p21 [279,395,396].”
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References 36 · Cited by 189
- Authors
- Gueler, F., Gwinner, W., Schwarz, A., & Haller, H.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- Haller, Hermann
- ORCID
- Haller, Hermann
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 66
- Issue
- 2
- Pages
- 523-527
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W1984783960
- Cited by
- 189
- References
- 36
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 9 · 2019: 5 · 2018: 10 · 2017: 18 · 2016: 10 · 2015: 11 · 2014: 14 · 2013: 11 · 2012: 5
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- ischemia-reperfusion injury, kidney transplantation, delayed graft function, inflammatory cell infiltration, adhesion molecules, heme oxygenase-1, acute kidney injury, protocol biopsy, histological changes
- MeSH terms
- Animals, Humans, Kidney, Reperfusion Injury, Kidney Transplantation
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