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Cited by 80Nonmelanoma Skin Cancer StudiesSkin Protection and AgingCancer and Skin Lesions

The DOI matches its Crossref record; 259 of the 259 references it cites were found in a registry or an index.

The actinic keratosis: A perspective and update

SCHWARTZ, ROBERT A.·1997·Dermatologic Surgery
DOI 10.1111/j.1524-4725.1997.tb00438.x
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Abstract

BACKGROUND: Actinic keratosis (AK) is a common sun-induced precancerous neoplasm confined to the epidermis. It is the initial manifestation of a continuum of clinical and histologic abnormalities that progresses to invasive squamous cell carcinoma (SCC), a disorder that accounts for thousands of preventable deaths in America each year. OBJECTIVE: The purpose of this work is to describe the actinic keratosis. METHODS: This effort was performed by a literature review and analysis. RESULTS: Like SCCs, the vast majority of AKs are asymptomatic. Although some actinic keratoses may become clinically inapparent, possibly either due to immune rejection or simply having their external surface unknowingly scraped off, an untreated AK represents a potentially curable fatal cancer. CONCLUSIONS: Each AK should be treated before it progresses to invasive squamous cell carcinoma. Destructive modalities such as cryosurgery using liquid nitrogen and electrodesiccation and curettage are the mainstays of therapy. Each case must be individualized. LEARNING OBJECTIVES: After studying this article, participant should be able to: 1. Understand the concept of an actinic keratosis. 2. Learn how to recognize its clinical manifestations. 3. Be aware of the danger it poses as an easily curable papulonodule that may become a fatal cancer.

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Items 201–259 of 259

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  1. Schwartz RA Stoll HL , Jr. Epithelial neoplasms and precancer-ous lesions Freedberg IM Eisen AZ Wolff LA et al Dermatology in General Medicine 5th ed. McGraw-Hill
  2. Dubreuilh, 1898, Third International Congress of Dermatology held in the examination hall of the conjoint Royal Colleges of Physicians and Surgeons. London, August 4th to 8th, 1896. Official Transactions. 1896, 125
  3. Unna, 1898, Third International Congress of Dermatology held in the examination hall of the conjoint Royal Colleges of Physicians and Surgeons. London, August 4th to 8th, 1896. Official transactions. 1896, 95
  4. Duhreuilh, 1907, Épithéliomatose d'origine solaire, Ann Dermatol Syphiligr (Paris), 38, 387
  5. Darier, 1920, A text-book of dermatology by J. Darier. Authorized translation from the second French edition edited with notes by S. Pollitzer, 209
  6. Freudenthal, 1929, Rumpfhautepitheliom (nebst Bemerkungen über die Verruca senilis und das Keratoma senilis, Arch f Dermat u Syph (Berlin), 158, 539
  7. Lambert, 1988, Evidence for origin of basal cell carcinoma in solar (actinic) keratoses, J Cutan Pathol, 15, 322
  8. Bloch, 1932, Cancers and precancerous affections from the derma-tological viewpoint, Cancer Rev, 7, 65
  9. Hurwitz, 1995, Solar keratosis: an evolving squamous cell carcinoma. Benign or malignant?, Dermatol Surg, 21, 183, 10.1016/1076-0512(94)00269-V · DOI
  10. Schwartz RA Stoll HL , Jr. Squamous cell carcinoma Freedberg IM Eisen AZ Wolff K et al Dermatology in General Medicine McGraw-Hill
  11. Graham, 1966, Advances in Biology of Skin, 277
  12. Jablonska, 1961, Zmiany nowotworowe cechujace sie dyskeratoza typu Dariera. II. Cz. nabloniaki (raki) dyskeratoty-czne, Przegl Dermatol, 48, 195
  13. O'Beirn, 1970, Proceedings of the Sixth National Cancer Conference, 489
  14. Dubin, 1986, Epidemiology of malignant melanoma: pigmentary traits, ultraviolet radiation, and the identification of high-risk populations. Recent results, Cancer Res, 102, 56
  15. Schwartz, 1982, Cancer Medicine, 109
  16. Lambert, 1995, Skin cancer: mechanisms and human relevance, 39
  17. Graham, 1997, Solar keratosis with squamous cell carcinoma (SK-SCC), J Cutan Pathol, 24, 100
  18. Bito, 1995, Cyclin D expression in solar keratosis and SCC in relation to p53 and RB protein expression (abstract), J Invest Dermatol, 104, 634
  19. Freeman, 1984, What is the boundary that separates a thick solar keratosis from a thin squamous-cell carcinoma?, Am J Dermatopathol, 301
  20. D'Errico, 1996, The role of p53 mutations in skin cancer, Chron Dermatol (Roma), 6, 27
  21. Umbert, 1995, Actinic keratosis with follicular invasion, J Cutan Pathol, 22, 76
  22. Civatte, 1973, Hyperplasie pseudo-epithelio-mateuse du dos des mains, Ann Dermatol Syphiligr (Paris), 100, 29
  23. Moreno, 1984, Queratosis actinica pigmentada centrifuga, Medicina Cutanea Ibero-Latino-Amer, 12, 379
  24. Crocker, 1893, Diseases of the Skin. Their Description, Pathology, Diagnosis and Treatment with Special Reference to the Eruptions of Children, 396
  25. Mehregan, 1965, Cutaneous horn: a clinicopathologic study, Dermatol Digest, 4, 45
  26. Bart, 1976, Cutaneous horns, 557
  27. Johnson, 1844, St. George's Hospital. Report of some cases occurring amongst the out-patients, treated by Henry James Johnson, Esq., Senior-Assistant Surgeon. Case 1.-“Horn” growing from the scrotum-its sebaceous origin-chimney-sweeper's cancer subsequently developed, Lancet, ii, 810
  28. Krysiak, 1995, Congressus Dermatologiae 23-25. 06.1995. Lodz. Streszczenie referatow, 210
  29. Michalowski, 1993, Cheilitis actinica with heterotopic salivary glands (Michalowski's syndrome): its operative treatment: report of two cases, Postépy Dermatol, 10, 9
  30. Katzenellenbogen, 1976, Cancer of the Skin Biology-Diagnosis-Management, 607
  31. Pompe-Kirn, 1992, Trends in incidence of skin and lip carcinomas and malignant melanoma of the skin in Slovenia, Acta Derm Veneroi Alp Panon Adriat (Ljubljana), 2, 41
  32. D'Hermies, 1992, Keratose actinique bilaterale du limbe. A propos d'une observation, J Fr Ophtalrnol, 15, 65
  33. Bravo-Piris, 1991, Dermatology in Europe. Proceedings of the 1st Congress of the European Academy of Dermatology and Venereology, Florence, Italy 25-28 September 1989, 813
  34. Jabloŕiska, 1961, Zmiany nowotworowe cechujace sie dyskeratoza tvpu Dariera. Czȩść I. Lagodne guzy dyskerato-tyczne, Przegl Dermatol, 48, 89
  35. Chorzelski, 1962, Przypadek Przejsćia ro-gowacenia starczego z dyskeratozα typu Dariera w nabloniak dyskeratotyczny (epithelioma dyskeratoticum segregans), Przegl Dermatol, j49, 29
  36. Pinkus, 1958, Keratosis senilis. A biological concept of its pathogen-esis and diagnosis based on the study of normal epidermis and 1,730 seborrheic and senile keratoses, Ann J Clin Pathol, 23, 193, 10.1093/ajcp/29.3.193 · DOI
  37. Rio, 1996, Clinico-pathological concordance of the large cell acanthoma, J Cutan Pathol, 23, 71
  38. Navarro, 1995, Poroquera-tosis actinica superficial diseminada: estudio clínico, histológico, immunorustoquímico y ultraestructural, Medicina Cutanea Ibero-Lat-Am, 23, 98
  39. Kinney, 1986, Necrotizing sialometaplasia: a sheep in Wolf's clothing, Arch Dermatol, 122, 208, 10.1001/archderm.1986.01660140098027 · DOI
  40. Johnson, 1978, National center for health statistics. Skin conditions and related need for medical care among persons 1-74. United States, 1971-1974, Vital Health Statistics, 11, 1
  41. Szepietowski, 1995, Clinical spectrum of skin infections, and premaiignant and malignant skin lesions in renal transplant recipients, Przegl Dermatol, 82, 465
  42. Harwood, 1996, Aggressive spindle cell squamous cell carcinoma in renal transplant recipients, Br J Dermatol, 135, 23
  43. Kaszuba, 1995, Kriotherapia podtlenkeim azotu (N2O) w prakryce dermatologicznej, Przegl Dermatol, 82, 547
  44. Drake, 1995, Guidelines of care for actinic keratoses, J Am Acad Dermatol, 32, 95, 10.1016/0190-9622(95)90191-4 · DOI
  45. Falkson, 1962, Skin changes in patients treated with 5-fluorouracil, Br J Dermatol, 74, 229, 10.1111/j.1365-2133.1962.tb13497.x · DOI
  46. Klein, 1962, Tumors of the skin. I. Effects of local use of cytostatic agents, Skin, l, 81
  47. Burgess, 1974, Effect of topical tubercidin on basal cell carcinomas and actinic keratoses, Cancer, 34, 250, 10.1002/1097-0142(197408)34:2<250::AID-CNCR2820340204>3.0.CO;2-X · DOI
  48. Belisario, 1970, Ten years' experience with topical cytotoxic therapy for cutaneous cancer and precancer: type and number of lesions treated, (part I), Cutis, 6, 293
  49. Belisario, 1970, Ten years' experience with topical cytotoxic therapy for cutaneous cancer and precancer: type and number of lesions treated, (part II), Cutis, 6, 402
  50. Klein, 1982, Cancer Medicine, 2057
  51. Klein, 1980, Clinical Immunotherapy, 31
  52. Simmonds, 1973, Double-blind investigation comparing a 1%- vs-5% 5-fluorouracil topical cream in patients with multiple actinic keratoses, Cutis, 12, 615
  53. Kulp-Shorten, 1993, Comparative evaluation of the efficacy and safety of masoprocol and 5-fluorouracil cream for the treatment of multiple actinic keratoses of the head and neck, J Geriatr Dermatol, 1, 161
  54. Brown, 1995, A comparative evaluation of masoprocol vs 5-fluorouracil for the treatment of actinic keratoses, J Invest Dermatol, 104, 694
  55. Strzelczyk, 1992, Advances in Pathogenesis, Diagnosis and Treatment of Skin and Venereal Diseases. Proceedings of the 24th Congress of the Polish Dermatologic Society. Gdansk, September 1992, 24-26. Drukamia Archidiecezji Gdańiskiej, Gdańsk, 790
  56. Kazmierowski, 1985, Dermatologiczne wskazania do krioterapii plynnym azotem i podtlenkiem azotu ze szczegól-nym uwzglednieniem nowotworow skóry, Przegl Dermatol, 72, 330
  57. Kuflik, 1993, Clinical Dermatology, 1
  58. Placek, 1995, Congressus Dermatologiae 23-25. 06. 1995. Lódź. Streszczenie Referatów, 212
  59. Eckert, 1995, Skin Cancer: Mechanisms and Human Relevance, 361
  60. Noszczyk, 1993, Mechanizmy starzenia siȩ skóry oraz zapobiegawcze dzialanie retinoidów, Przegl Dermatol, 80, 441
  61. Kaźmierowski, 1993, Retinoidy w leczeniu raków i chioniakow skóry, Postepy Dermatol, 10, 137
  62. Chen, 1995, Skin Cancer: Mechanisms and Human Relevance, 401
  63. Skopińska, 1995, Congressus Dermatologiae 23-25. 06.1995. Lódz. Streszczenie Referatów, 44
  64. Noszczyk, 1997, The mechanisms of action of retinoids in the treatment of photoaged skin, Przegl Dermatol, 84, 223
  65. Verma, 1995, Skin Cancer: Mechanisms and Human Relevance, 383
  66. Agarwal, 1995, Skin Cancer: Mechanisms and Human Relevance, 391
  67. Fitzpatrick, 1995, Use of the ultrapulse CO2 laser for dermatology including facial resurfacing, Lasers Surg Med, 15, 50
  68. Sidorowicz, 1992, Advances in Pathogenesis, Diagnosis and Treatment of Skin and Venereal Diseases. Proceedings of the 24th Congress of the Polish Derma-tologic Society. Gdansk, September 1992, 24-26, 860
  69. Rubisz-Brzezińska, 1993, Przydatność lasera wysokoenergetycznego Nd: YAG w terapii nabloniaków pod-stawnokomórkowych skóry i niektórych stanow przednowot-worowych, Przegl Dermatol, 80, 469
  70. Coleman, 1996, Dermabrasioti for prophvlaxis and treatment of actinic keratoses, Dermatol Surg, 22, 17, 10.1016/1076-0512(95)00428-9 · DOI
  71. Ditre, 1995, The effects of alpha hydroxyacids (AHAs) on photoaged skin: a pilot clinical, histo-logical and ultrastrucrural study, J Invest Dermatol, 104, 690

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Authors
SCHWARTZ, R. A.
Affiliations
Rutgers New Jersey Medical School (US)
Corresponding author
SCHWARTZ, ROBERT A.
ORCID
SCHWARTZ, ROBERT A.
Venue
Dermatologic Surgery
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1997-11
Volume
23
Issue
11
Pages
1009-1019
ISSN
1076-0512 (ISSN-L)
DOI
10.1111/j.1524-4725.1997.tb00438.x
OpenAlex
W2073581208
Cited by
80
References
259
Citations by year
2026: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 3 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 10
FWCI
0.86
Type
journal article
Language
en
Open access
closed
Locations
  • Dermatologic Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Dermatology › Cancer and Skin Lesions
Keywords
actinic keratosis, squamous cell carcinoma, precancerous skin lesions, sun damage, epidermal lesions, cryosurgery, actinic keratosis treatment, clinical features
MeSH terms
Carcinoma, Squamous Cell, Humans, Keratosis, Neoplasms, Radiation-Induced, Precancerous Conditions, Skin Neoplasms, Sunlight, Incidence, Prevalence

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