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Cited by 11Electromagnetic Fields and Biological EffectsPain Mechanisms and TreatmentsPain Management and Treatment

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Effects on Rats of Low Intensity and Frequency Electromagnetic Field Stimulation on Thoracic Spinal Neurons Receiving Noxious Cardiac and Esophageal Inputs

Qin, Chao, Evans, J. Mark, Yamanashi, William S., Scherlag, Benjamin J., Foreman, Robert D.·2005·Neuromodulation: Technology at the Neural Interface
DOI 10.1111/j.1525-1403.2005.00223.x
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Abstract

Objective Low intensity and low frequency electromagnetic field stimulation (EMFs) provides substantial pain relief in patients with various chronic pains. The aim of this study was to examine the effects of EMFs on the activity of thoracic spinal neurons responding to noxious visceral stimuli. Materials and Methods Extracellular potentials of single T(3) -T(4) spinal neurons were recorded in pentobarbital anesthetized male rats. A catheter was placed in the pericardial sac to administer a mixture of algogenic chemicals for noxious cardiac stimulation (0.2 mL, 1 min). Noxious esophageal distension was produced by water inflation (0.4 mL, 20 sec) of a latex balloon. EMFs (0.839-0.952 Hz, 0.030-0.034 µG, 30-40 min) was applied with a pair of Helmholtz coils placed on both sides of the chest. Results After the onset of EMFs, excitatory neuronal responses to intrapericardial chemicals were reduced in 24/32 (75%) spinal neurons, increased in three neurons and were not affected in five neurons. The inhibitory effect on spinal neurons occurred 10-20 min after the onset of EMFs. Even after termination of EMFs, the suppression of spinal neuronal activity lasted for 1-2 hr. In contrast, excitatory responses of 7/18 (39%) neurons to esophageal distension were inhibited, five (28%) were excited and six (33%) were not affected by EMFs. Conclusions Results showed that EMFs generally reduced nociceptive responses of spinal neurons to noxious cardiac chemical stimuli, whereas it was not effective for nociceptive responses to esophageal mechanical stimulation.

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Crossref · 10.1111/j.1525-1403.2005.00223.x

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Research works printed but not linked: 26

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Metadata

Authors
Qin, C., Evans, J. M., Yamanashi, W. S., Scherlag, B. J., & Foreman, R. D.
Affiliations
University of Oklahoma Health Sciences Center (US)
Corresponding author
Qin, Chao
ORCID
Venue
Neuromodulation: Technology at the Neural Interface
Publisher
Elsevier BV
Published
2005-04
Volume
8
Issue
2
Pages
79-87
ISSN
1094-7159 (ISSN-L)
DOI
10.1111/j.1525-1403.2005.00223.x
OpenAlex
W1510929756
Cited by
11
References
2
Citations by year
2026: 1 · 2024: 1 · 2020: 1 · 2017: 1 · 2016: 4 · 2015: 2 · 2012: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neuromodulation Technology at the Neural Interface (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords
electromagnetic field stimulation, visceral nociception, cardiac pain, esophageal distension, Helmholtz coil, extracellular potentials, analgesia

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