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Nanobioengineered Electrospun Composite Nanofibers and Osteoblasts for Bone Regeneration
Open accessAbstract
Abstract: Bone defects represent a medical and socioeconomic challenge. Engineering bioartificial bone tissues may help to solve problems related to donor site morbidity and size limitations. Nanofibrous scaffolds were electrospun into a blend of synthetic biodegradable polycaprolactone (PCL) with hydroxyapatite (HA) and natural polymer gelatin (Gel) at a ratio of 1:1:2 (PCL/HA/Gel) compared to PCL (9%), PCL/HA (1:1), and PCL/Gel (1:2) nanofibers. These fiber diameters were around 411 ± 158 to 856 ± 157 nm, and the pore size and porosity around 5–35 µm and 76–93%, respectively. The interconnecting porous structure of the nanofibrous scaffolds provides large surface area for cell attachment and sufficient space for nutrient transportation. The tensile property of composite nanofibrous scaffold (PCL/HA/Gel) was highly flexible and allows penetrating osteoblasts inside the scaffolds for bone tissue regeneration. Fourier transform infrared analysis showed that the composite nanofiber contains an amino group, a phosphate group, and carboxyl groups for inducing proliferation and mineralization of osteoblasts for in vitro bone formation. The cell proliferation (88%), alkaline phosphatase activity (77%), and mineralization (66%) of osteoblasts were significantly (P < 0.001) increased in composite nanofibrous scaffold compared to PCL nanofibrous scaffolds. Field emission scanning electron microscopic images showed that the composite nanofibers supported the proliferation and mineralization of osteoblast cells. These results show that the fabrication of electrospun PCL/HA/Gel composite nanofibrous scaffolds has potential for the proliferation and mineralization of osteoblasts for bone regeneration.
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Citations
Cited by
Nanofibers for Biomedical and Healthcare Applications
Rasouli, R., Barhoum, A., Bechelany, M., & Dufresne, A. (2019) · Macromolecular Bioscience · doi:10.1002/mabi.201800256 · Cited by 319
Gupta, D., Venugopal, J., Mitra, S., Giri Dev, V. R., & Ramakrishna, S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.079 · Cited by 317
Self-citationElectrospun composite nanofibers and their multifaceted applications
Sahay, R., Kumar, P. S., Sridhar, R., Sundaramurthy, J., Venugopal, J., Mhaisalkar, S. G., & Ramakrishna, S. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm30966a · Cited by 299
Self-citationPolymer Fiber Scaffolds for Bone and Cartilage Tissue Engineering
Zhang, Y., Liu, X., Zeng, L., Zhang, J., Zuo, J., Zou, J., Ding, J., & Chen, X. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201903279 · Cited by 294
Electrospun cellular microenvironments: Understanding controlled release and scaffold structure
Szentivanyi, A., Chakradeo, T., Zernetsch, H., & Glasmacher, B. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.12.002 · Cited by 271
Metadata
- Authors
- Venugopal, J. R., Low, S., Choon, A. T., Kumar, A. B., & Ramakrishna, S.
- Venue
- Artificial Organs
- Publisher
- Wiley
- Published
- 2008-05
- Volume
- 32
- Issue
- 5
- Pages
- 388-397
- ISSN
- 0160-564X (ISSN-L)
- 1525-1594
- OpenAlex
- W2024727569
- Cited by
- 244
- References
- 0
- FWCI
- 11.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Venugopal, J. R., Low, S., Choon, A. T., Kumar, A. B., & Ramakrishna, S. (2008). Nanobioengineered Electrospun Composite Nanofibers and Osteoblasts for Bone Regeneration. Artificial Organs. https://doi.org/10.1111/j.1525-1594.2008.00557.x
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