The DOI matches its Crossref record.
Caffeine Consumption, Withdrawal and Cerebral Blood Flow
Abstract
SYNOPSIS Regional cerebral blood flow (CBF) measurements were conducted under resting conditions and after twenty‐four hours of caffeine abstinence in groups of high and low caffeine users. CBF was also measured thirty minutes after the oral administration of 250 rag. of caffeine in the high caffeine users and after a placebo in the low caffeine users. Caffeine administration was associated with significant CBF reduction and caffeine abstinence with significant frontal flow increases in the high caffeine group. The low caffeine group showed no differences between the resting, post‐placebo and post‐caffeine abstinence CBF values.
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“Earlier, Mathew et al. demonstrated that cerebral blood flow decreases with caffeine ingestion [13,40].”
From Central and peripheral effects of sustained caffeine use: tolerance is incomplete (2002) · cites this paper as [40]
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Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624
“This decrease can be achieved in humans after the absorption of 250 mg of caffeine (Mathew and Wilson, 1985; Cameron et al., 1990).”
Nehlig, A., Daval, J., & Debry, G. (1992) · Brain Research Reviews · doi:10.1016/0165-0173(92)90012-b · Cited by 1,463
Juliano, L. M., & Griffiths, R. R. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2000-x · Cited by 613
“The magnitude of this effect is positively correlated with daily caffeine dose before abstinence (Mathew and Wilson 1985; Field et al. 2003).”
Are we dependent upon coffee and caffeine? A review on human and animal data
Nehlig, A. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(98)00050-5 · Cited by 453
“This recent study confirms several previous ones that suggested that increased blood volume may be involved in caffeine withdrawal headaches [48] [94] [133] [194].”
ResultCaffeine physical dependence: a review of human and laboratory animal studies
Griffiths, R. R., & Woodson, P. P. (1988) · Psychopharmacology · doi:10.1007/bf00212836 · Cited by 276
Metadata
- Authors
- Mathew, R. J., & Wilson, W. H.
- Affiliations
- Vanderbilt University (US)
- Venue
- Headache: The Journal of Head and Face Pain
- Publisher
- Wiley
- Published
- 1985-09
- Volume
- 25
- Issue
- 6
- Pages
- 305-309
- ISSN
- 0017-8748 (ISSN-L)
- 1526-4610
- OpenAlex
- W2049908803
- Cited by
- 55
- References
- 0
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Headache The Journal of Head and Face Pain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 36117-01A1)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- caffeine, caffeine withdrawal, regional cerebral blood flow, caffeine abstinence, caffeine dependence
- MeSH terms
- Adult, Caffeine, Cerebrovascular Circulation, Female, Humans, Male, Middle Aged, Substance Withdrawal Syndrome
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