Topiramate as Add‐On Therapy: Pooled Analysis of Randomized Controlled Trials in Adults

Abstract

Summary: Purpose: Six double‐blind, placebo‐controlled trials were conducted with topiramate (TPM) initiated as adjunctive therapy in adults with treatment‐resistant partial‐onset seizures with or without secondary generalization. Methods: Because protocols and study populations were similar, data from the studies were pooled and analyzed for 527 patients treated with TPM and 216 treated with placebo. Results: Seizures were reduced 50% in 43% of TPM‐treated patients and in 12% of placebo‐treated patients (p < 0·001); 5% of TPM‐treated patients, but no placebo‐treated patients, were seizure free during 11–19 weeks of double‐blind treatment (p < 0·001). The therapeutic effect was consistent regardless of seizure type, age, gender, baseline seizure rate, or concomitant antiepileptic drug (AED). With 100 mg/day TPM as a starting dosage and weekly dosage increments of 100–200 mg/day added to maximally tolerated dosages of AEDs, the most common treatment‐emergent adverse events (TEAEs) were dizziness, somnolence, fatigue, psychomotor slowing, nervousness, paresthesia, ataxia, memory difficulty and speech problems. These central nervous system effects were generally mild to moderate in severity, usually occurred early in treatment, often during titration, and resolved with continued treatment. Other notable TEAEs were weight loss and, in a small percentage of patients, renal calculi.