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Contralateral Smile and Laughter, but No Mirth, Induced by Electrical Stimulation of the Cingulate Cortex
Abstract
The cerebral representation of laughter is dissociated. The emotional aspects seem to be processed in the temporal lobe; whereas the motor features apparently rely on the frontal cortex. In a few prior studies of patients in whom laughter was elicited by electrical stimulation (ES), it always was associated with mirth. We report a patient in whom ES in the right cingulate gyrus elicited smile and laughter, but no mirth. At low voltages, smiling was seen first contralaterally and became bilateral with increasing currents. Our observation supports the concept of the motor representation of laughter in the mesial frontal cortex.
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iES of the ACC has resulted in reports of the urge to move, the urge to laugh, and the actual motor expression of laughter and smiling.
“iES of the ACC has resulted in intriguing reports of the urge to move (Kremer et al., 2001) and to laugh (Chassagnon et al., 2008), as well as the actual motor expression of laughter and smiling (Sperli et al., 2006).”
From Does the Prefrontal Cortex Play an Essential Role in Consciousness? Insights from Intracranial Electrical Stimulation of the Human Brain (2021) · cites this paper as Sperli et al., 2006
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Electric current stimulates laughter
Fried, I., Wilson, C. L., MacDonald, K. A., & Behnke, E. J. (1998) · Nature · doi:10.1038/35536 · Cited by 227
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Guillory, S. A., & Bujarski, K. A. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu002 · Cited by 127
Raccah, O., Block, N., & Fox, K. C. R. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.1141-20.2020 · Cited by 96
Metadata
- Authors
- Sperli, F., Spinelli, L., Pollo, C., & Seeck, M.
- Affiliations
- University of Rome Tor Vergata (IT)
- Centre Hospitalier Universitaire Vaudois (CH)
- Corresponding author
- Seeck, Margitta
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2006-02
- Volume
- 47
- Issue
- 2
- Pages
- 440-443
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W2094082965
- Cited by
- 94
- References
- 1
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 15 · 2022: 8 · 2021: 3 · 2020: 5 · 2019: 8 · 2018: 3 · 2017: 3 · 2016: 6 · 2015: 1 · 2014: 7 · 2013: 8 · 2012: 2
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Epilepsia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Humor Studies and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Neurology › Neurology and Historical Studies
- Keywords
- laughter, smiling, cingulate cortex, electrical stimulation, mirth, emotional expression, temporal lobe, frontal lobe
- MeSH terms
- Adult, Brain Mapping, Cerebral Cortex, Cysteine, Electric Stimulation, Electrodes, Implanted, Electroencephalography, Frontal Lobe, Gyrus Cinguli, Humans, Functional Laterality, Laughter, Male, Models, Neurological, Seizures, Smiling, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon, Fluorodeoxyglucose F18, Imaging, Three-Dimensional, Positron-Emission Tomography
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