A cellular mechanism for dendritic spine loss in the pilocarpine model of status epilepticus

Kurz, Jonathan E.; Moore, Bryan J.; Henderson, Scott C.; Campbell, John N.; Churn, Severn B.

doi:10.1111/j.1528-1167.2008.01616.x

A cellular mechanism for dendritic spine loss in the pilocarpine model of status epilepticus

Summary Purpose: Previous studies have documented a synaptic translocation of calcineurin (CaN) and increased CaN activity following status epilepticus (SE); however, the cellular effect of these changes in CaN in the pathology of SE remains to be elucidated. This study examined a CaN‐dependent m…