Lower Cardiac Output Is Associated with Greater White Matter Hyperintensities in Older Adults with Cardiovascular Disease

Jefferson, Angela L.; Tate, David F.; Poppas, Athena; Brickman, Adam M.; Paul, Robert H.; Gunstad, John; Cohen, Ronald A.

doi:10.1111/j.1532-5415.2007.01226.x

Lower Cardiac Output Is Associated with Greater White Matter Hyperintensities in Older Adults with Cardiovascular Disease

OBJECTIVES: To preliminarily examine the association between cardiac output, a measure of systemic blood flow, and structural brain magnetic resonance imaging indices of white matter hyperintensities (WMHs). DESIGN: Cross‐sectional. SETTING: University medical setting. PARTICIPANTS: Thirty‐six ol…