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The effect of whole-blood donor adverse events on blood donor return rates
Open accessAbstract
BACKGROUND: Some blood donation-related adverse events (AEs) can negatively impact the blood donor return rate (BDRR) and decrease donor retention. STUDY DESIGN AND METHODS: One-thousand randomly selected whole-blood donors were interviewed 3 weeks after a 525-mL index whole-blood donation for seven AEs. The number of return visits and duration of follow-up were recorded for each of the 1000 donors. A negative binomial regression analysis was used to determine the contribution of the four most common AEs to the BDRR, and interactions between these AEs were also evaluated. RESULTS: The four most common AEs were bruise alone (15.1%), sore arm "alone" (7.0%), fatigue "alone" (5.1%), and donor reaction "alone" (4.2%), where "alone" is defined to also include donors who had a bruise but no other AE. The estimated BDRR for donations without AEs was 1.32 visits per year. The estimated BDRRs for the four most common AEs were: bruise alone, 1.32 visits per year; sore arm alone, 1.30 visits per year (2% reduction in BDRR); fatigue alone, 1.06 visits per year (20% reduction in BDRR); and donor reaction alone, 0.87 visits per year (34% reduction in BDRR). The BDRR for donor reaction, fatigue, and sore arm together was 0.20 visits per year (85% reduction in BDRR). CONCLUSION: Donor reaction had the most negative impact on the BDRR. There appears to be a synergistic effect between donor reaction, fatigue, and sore arm. Theoretically, amelioration of some AEs has the potential to improve BDRRs.
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Desai, R., Mills, R., Masser, B., Jones, T., Edwards, T. J., Brailsford, S. R., O'Hagan, N., Washington, C., & Eamonn, F. (2026) · Transfusion · doi:10.1111/trf.70081
Impact of environmental factors on adverse events in whole blood donation
Roy, R., Sonia, F. A., Saha, S., Perveen, M. S., Hasan, M. M., & Karmaker, R. K. (2026) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20260940
Thijsen, A., Thorpe, R. D., & Masser, B. (2026) · Transfusion · doi:10.1111/trf.70216
Padilla, N. D., Snel, A., Rashid, M., Bank, I., & Wiersum‐Osselton, J. C. (2026) · Vox Sanguinis · doi:10.1111/vox.70349
Kumar, S., Chandra, T., Solanki, A., Singh, A., & Kumari, N. (2026) · Cureus · doi:10.7759/cureus.115261
Metadata
- Authors
- Newman, B. H., Newman, D. T., Ahmad, R., & Roth, A. J.
- Affiliations
- American Red Cross (US)
- Corresponding author
- Newman, Bruce H.
- ORCID
- Newman, Daniel T.
- Venue
- Transfusion
- Publisher
- Wiley
- Published
- 2006-07-28
- Volume
- 46
- Issue
- 8
- Pages
- 1374-1379
- ISSN
- 0041-1132 (ISSN-L)
- 1537-2995
- OpenAlex
- W2103869157
- Semantic Scholar
- 57a6f1e059eed2bc0beede98e19a998f0fe7a0ea
- Cited by
- 190
- References
- 17
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 20 · 2021: 11 · 2020: 13 · 2019: 8 · 2018: 7 · 2017: 11 · 2016: 10 · 2015: 12 · 2014: 11 · 2013: 8 · 2012: 15
- FWCI
- 16.78
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Transfusion (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Blood donation and transfusion practices
- Health Sciences › Medicine › Hematology › Blood transfusion and management
- Social Sciences › Sociology and Political Science › Nonprofit Sector and Volunteering
- Keywords
- donor retention, whole blood donation, donor reactions, bruising, blood donation safety
- MeSH terms
- Blood Donors, Blood Transfusion, Contusions, Fatigue, Humans, Interviews as Topic, Pain, Time Factors
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