The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification of an optimal concentration of platelet gel for promoting angiogenesis in human endothelial cells
Abstract
BACKGROUND: Numerous studies have supported the use of topical blood components to improve wound healing and tissue regeneration. Platelet gel (PG), a hemocomponent obtained from mix of activated platelets (PLTs) and cryoprecipitate, is currently being used clinically in an attempt to improve tissue healing. The present study sought to define the most effective PG concentration to promote angiogenesis in vitro. STUDY DESIGN AND METHODS: The effects of PG‐released supernatant at different concentrations on human endothelial cells were studied using different in vitro assays (proliferation, migration, invasion, cord formation, and wound healing). RESULTS: The concentration of PG‐released supernatant had a significant influence on the angiogenic potential of endothelial cells. The optimal concentration for the stimulation of angiogenesis was 1.5 × 10 6 PLTs per µL in most of the in vitro experiments used in this study. Lower or higher concentrations of PG displayed a lower angiogenic potential. CONCLUSION: An optimal concentration of PG to promote angiogenesis in human endothelial cells was identified. Excessively high PG concentrations may inhibit the angiogenic process, thereby being counterproductive for wound healing in a clinical setting.
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Growth Factors and Wound Healing
Steenfos, H. H. (1994) · Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery · doi:10.3109/02844319409071186 · Cited by 192
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DeLong, J. M., Russell, R. P., & Mazzocca, A. D. (2012) · Arthroscopy: The Journal of Arthroscopic & Related Surgery · doi:10.1016/j.arthro.2012.04.148 · Cited by 623
The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial
Gentile, P., Garcovich, S., Bielli, A., Scioli, M. G., Orlandi, A., & Cervelli, V. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0107 · Cited by 361
Montalvan, B., Le Goux, P., Klouche, S., Borgel, D., Hardy, P., & Breban, M. (2016) · Rheumatology · doi:10.1093/rheumatology/kev326 · Cited by 92
Everts, P. A., Mazzola, T., Mautner, K., Randelli, P. S., & Podesta, L. (2022) · Biomedicines · doi:10.3390/biomedicines10112933 · Cited by 34
Metadata
- Authors
- Giusti, I., Rughetti, A., D'Ascenzo, S., Millimaggi, D., Pavan, A., Dell'Orso, L., & Dolo, V.
- Venue
- Transfusion
- Publisher
- Wiley
- Published
- 2009-03-20
- Volume
- 49
- Issue
- 4
- Pages
- 771-778
- ISSN
- 0041-1132 (ISSN-L)
- 1537-2995
- OpenAlex
- W2141651735
- Cited by
- 205
- References
- 1
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Giusti, I., Rughetti, A., D'Ascenzo, S., Millimaggi, D., Pavan, A., Dell'Orso, L., & Dolo, V. (2009). Identification of an optimal concentration of platelet gel for promoting angiogenesis in human endothelial cells. Transfusion. https://doi.org/10.1111/j.1537-2995.2008.02033.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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