The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Release of Cardiac Biochemical and Inflammatory Markers in Patients on Cardiopulmonary Bypass Undergoing Coronary Artery Bypass Grafting
Open accessAbstract
BACKGROUND: Determination of cardiac markers can assess cardiac injury induced by cardiopulmonary bypass (CPB) during coronary artery bypass grafting (CABG). However, the markers and their release pattern are not well defined. This study was aimed at assessing the release and timing of cardiac biochemical and inflammatory markers in patients undergoing elective CABG with CPB. METHODS: Forty patients undergoing elective CABG were included in this study. Blood samples were collected for biochemical measurements at the following time points: immediately prior to the induction of anesthesia, one, six, 12, and 24 hours after initiation of CPB. RESULTS: Increased release of cardiac troponin I was observed one hour after initiation of CPB (p < 0.05) and reached the maximum at 12 hours after CPB (p < 0.01). Serum CK-MB enzyme activity and CK-MB mass both were highly elevated starting at one hour after initiation of CPB, peaked at six hours, and remained elevated until 24 hours after CPB. Both lactate and lactate dehydrogenase were highly elevated six hours after CPB and peaked at 12 hours after CPB (p < 0.01). Serum levels of interleukin-6 and tumor necrosis factor-alpha increased significantly one hour after initiation of CPB and peaked at six hours (p < 0.01), while serum high sensitivity C-reactive protein levels started to elevate 12 hours after CPB (p < 0.01). CONCLUSION: Monitoring of these markers could help to determine implementation of protective interventions during CABG with CPB to prevent myocardial deterioration and to predict the risk and prognosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Cardiopulmonary bypass (CPB) is an immuno-reactive state where neutrophils are activated and accumulate in different tissues.”
From Oral neutrophils are an independent marker of the systemic inflammatory response after cardiac bypass (2014) · cites this paper as [3]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Antman, E., Bassand, J.-P., Klein, W., Ohman, M., Lopez Sendon, J. L., Rydén, L., Simoons, M., & Tendera, M. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00804-4 · Cited by 4,821
It’s Time for a Change to a Troponin Standard
Jaffe, A. S., Ravkilde, J., Roberts, R., Naslund, U., Apple, F. S., Galvani, M., & Katus, H. (2000) · Circulation · doi:10.1161/01.cir.102.11.1216 · Cited by 643
A Randomized Comparison of Off-Pump and On-Pump Multivessel Coronary-Artery Bypass Surgery
Khan, N. E., De Souza, A., Mister, R., Flather, M., Clague, J., Davies, S., Collins, P., Wang, D., Sigwart, U., & Pepper, J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031282 · Cited by 615
Inflammatory response to cardiopulmonary bypass
Levy, J. H., & Tanaka, K. A. (2003) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(02)04701-x · Cited by 583
NACB WRITING GROUP MEMBERS, Morrow, D. A., Cannon, C. P., Jesse, R. L., Newby, L. K., Ravkilde, J., Storrow, A. B., Wu, A. H. B., Christenson, R. H., NACB COMMITTEE MEMBERS, et al. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.084194 · Cited by 474
Hennein, H. A., Ebba, H., Rodriguez, J. L., Merrick, S. H., Keith, F. M., Bronstein, M. H., Leung, J. M., Mangano, D. T., Greenfield, L. J., & Rankin, J. S. (1994) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(94)70286-1 · Cited by 405
Avoiding cardiopulmonary bypass in multivessel CABG reduces cytokine response and myocardial injury
Wan, S., Izzat, M. B., Lee, T. W., Wan, I. Y. P., Tang, N. L. S., & Yim, A. P. C. (1999) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(99)00315-x · Cited by 292
Cytokine Responses to Cardiopulmonary Bypass: Lessons Learned From Cardiac Transplantation
Wan, M., LeClerc, M., & Vincent, M. (1997) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(96)00931-9 · Cited by 263
Wan, S., DeSmet, J.-M., Barvais, L., Goldstein, M., Vincent, J., & LeClerc, J.-L. (1996) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(96)70068-5 · Cited by 251
Engström, G., Lind, P., Hedblad, B., Stavenow, L., Janzon, L., & Lindgärde, F. (2002) · Circulation · doi:10.1161/01.cir.0000017327.69909.ff · Cited by 194
Cited by
Hall, R. N. (2012) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2012.09.013 · Cited by 88
Jiménez, J. J., Iribarren, J. L., Brouard, M., Hernández, D., Palmero, S., Jiménez, A., Lorente, L., Machado, P., Borreguero, J., Raya, J. M., et al. (2011) · Journal of Cardiothoracic Surgery · doi:10.1186/1749-8090-6-138 · Cited by 79
Sohn, N., Marcoux, J., Mycyk, T. R., Krahn, J., & Meng, Q. (2009) · Perfusion · doi:10.1177/0267659109351218 · Cited by 66
Self-citationSohn, N., Marcoux, J., Mycyk, T. R., Krahn, J., Meng, Q., Gourlay, T., & Shedden, L. (2010) · Perfusion · doi:10.1177/0267659110381453 · Cited by 51
Self-citationSchulze, C. J., de Castro, M. M., Kandasamy, A. D., Cena, J., Bryden, C., Wang, S. H., Koshal, A., Tsuyuki, R. T., Finegan, B. A., & Schulz, R. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e318292373c · Cited by 39
Metadata
- Authors
- Meng, Q. H., Zhu, S., Sohn, N., Mycyk, T., Shaw, S. A., Dalshaug, G., & Krahn, J.
- Affiliations
- Department of Pathology and Laboratory Medicine
- Division of Cardiovascular Surgery, Department of Surgery
- Royal University Hospital (CA)
- ORCID
- Meng, Qing H.
- Venue
- Journal of Cardiac Surgery
- Publisher
- Hindawi Limited
- Published
- 2008-10-27
- Volume
- 23
- Issue
- 6
- Pages
- 681-687
- ISSN
- 0886-0440 (ISSN-L)
- 1540-8191
- OpenAlex
- W2120378164
- Cited by
- 32
- References
- 45
- Citations by year
- 2025: 1 · 2022: 2 · 2020: 1 · 2018: 2 · 2017: 4 · 2016: 3 · 2014: 4 · 2013: 4 · 2012: 3
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- onlinelibrary.wiley.com/termsAndConditions#vor (vor)
- doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
- Locations
- Journal of Cardiac Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Mechanical Circulatory Support Devices
- Keywords
- cardiopulmonary bypass, coronary artery bypass grafting, cardiac biomarkers, inflammatory markers, cardiac troponin I, CK-MB, lactate, lactate dehydrogenase, interleukin-6, TNF-α, high-sensitivity C-reactive protein, myocardial injury
- MeSH terms
- Adult, Aged, Coronary Artery Bypass, C-Reactive Protein, Cardiopulmonary Bypass, Female, Humans, Inflammation, L-Lactate Dehydrogenase, Male, Middle Aged, Prospective Studies, Tumor Necrosis Factor-alpha, Cohort Studies, Biomarkers, Interleukin-6, Oxidative Stress, Troponin I, Lactic Acid, Creatine Kinase, MB Form
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
