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A 5-year follow-up study of 3 polymorphisms in the human glucocorticoid receptor gene in relation to obesity, hypertension, and diabetes
Abstract
Glucocorticoid receptors (GRs) are cytoplasmatic receptors regulating the expression of cortisol and bind to specific sites on chromatin. The glucocorticoid receptor gene (GRL) is located on chromosome 5q31 and encodes for either a 777‐amino acid (GRα) or a 742‐amino acid (GRβ) polypeptide. The objective of the current study was to examine the prospective association of 3 polymorphisms—a Tth111I restriction fragment in the promoter region, a BclI polymorphism in intron 2, and an A/G polymorphism in exon 2—of the GRL gene on estimates of obesity, hypertension, and diabetes in 163 unrelated Swedish men born in 1944. These data showed a significant increase in body weight, body mass index, abdominal obesity, fasting glucose, insulin, and homeostasis model assessment over the 5‐year follow‐up among homozygotes for the rare BclI allele. In contrast, no significant associations with the Tth111I or A/G polymorphism were detected. It is concluded that the genetic information about GRL would be useful for further genetic study of obesity, diabetes, and related metabolic diseases.
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Interindividual sensitivity to glucocorticoids is influenced, in part, by polymorphisms in the glucocorticoid receptor gene, which have been associated with altered receptor function and differential metabolic responses to cortisol.
“This variability is influenced, in part, by polymorphisms in the glucocorticoid receptor gene, which have been associated with altered receptor function and differential metabolic responses to cortisol (102-108).”
From Measuring cortisol in Cushing syndrome: diagnosis, monitoring, and cortisol circadian rhythm improvement. (2026) · cites this paper as [104]
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Glucocorticoid receptor polymorphisms and haplotypes and their expression in health and disease
Koper, J. W., van Rossum, E. F. C., & van den Akker, E. L. T. (2014) · Steroids · doi:10.1016/j.steroids.2014.07.015 · Cited by 97
Glucocorticoid receptor polymorphism in obesity and glucose homeostasis
Majer-Łobodzińska, A., & Adamiec-Mroczek, J. (2017) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/41231 · Cited by 29
Glucocorticoid receptor polymorphisms influence muscle strength in Cushing's syndrome
Müller, L. M., Kienitz, T., Deutschbein, T., Riester, A., Hahner, S., Burger-Stritt, S., Berr, C. M., Oßwald, A., Braun, L., Rubinstein, G., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz052 · Cited by 17
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Hamidi, O., St-Jean, M., Lacroix, A., & Bancos, I. (2026) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgag095 · Cited by 5
Metadata
- Authors
- Rosmond, R., & Holm, G.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Corresponding author
- Rosmond, Roland
- ORCID
- Rosmond, Roland
- Venue
- Journal of the CardioMetabolic Syndrome
- Publisher
- Wiley
- Published
- 2008-06
- Volume
- 3
- Issue
- 3
- Pages
- 132-135
- ISSN
- 1559-4564 (ISSN-L)
- 1559-4572
- OpenAlex
- W1969321355
- Cited by
- 41
- References
- 5
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 3 · 2013: 5 · 2012: 1
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the CardioMetabolic Syndrome (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- glucocorticoid receptor gene, obesity, hypertension, diabetes mellitus, BclI polymorphism, A/G polymorphism, abdominal obesity, body mass index, insulin, HOMA, genetic susceptibility, metabolic disorders
- MeSH terms
- Alleles, Diabetes Mellitus, DNA, Follow-Up Studies, Gene Frequency, Genotype, Humans, Hypertension, Male, Middle Aged, Obesity, Polymorphism, Genetic, Prognosis, Receptors, Glucocorticoid, Retrospective Studies, Time Factors, Blotting, Southern, Polymerase Chain Reaction, Genetic Predisposition to Disease
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