The DOI matches its Crossref record.
Clinical and Upper Gastrointestinal Motility Features in Systemic Sclerosis and Related Disorders
Abstract
Objective The aim of this study was to characterize the clinical and motility findings in 62 patients with systemic sclerosis or related disorders referred for evaluation of upper gastrointestinal (GI) symptoms. Methods Methods included retrospective clinical record review and quantitation of esophageal, LES antral, and duodenal motility (3 h fasting, 2 h fed) were compared with results of 10 symptomatic patients with normal gastric emptying. Results A total of 46 patients had systemic sclerosis, eight mixed connective tissue disease, and eight polymyositis-systemic sclerosis overlap; systemic manifestations were almost invariably present. GI symptoms were: heartburn (77%), nausea/vomiting (58%), dysphagia (61%), diarrhea (53%), constipation (31%), and fecal incontinence (13%). Anatomical studies showed esophageal erosions or GERD (53%), aperistalsis (34%), stricture (29%), and Barrett's metaplasia (16%); megaduodenum, small bowel dilation, or diverticulae (42%); and pneumatosis intestinalis (8%). A total of 36 patients underwent esophageal and 26 esophagogastrointestinal manometry. Postprandial antral motility index was abnormal in 22 of 26; amplitudes and frequency in the antrum (34 +/- 3 mm Hg and 0.6 +/- 0.1/min, respectively) and duodenum (7.3 +/- 0.9 mm Hg and 1.8 +/- 0.5/min) were significantly lower than controls (p Conclusion In patients with GI symptoms associated with systemic sclerosis and related disorders, the amplitude and frequency of intestinal contractions a…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Advanced techniques, including antroduodenal‑jejunal manometry [71–75], wireless motility capsule [76–79], gastric ultrasound [80–82], and high‑resolution electrogastrography (EGG) [83–87] may provide additional pathophysiological insight, particularly in complex or mixed‑pattern cases.”
From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [75]
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 11
- Cohen S., 1980, Gastroenterology, 79, 155, 10.1016/0016-5085(80)90091-8 · DOI
- Sjogren R.W., 1994, Arthritis Rheuma, 37, 1265, 10.1002/art.1780370902 · DOI
- Poirier T.J., 1972, Am J Gastroenterol, 58, 30
- Lock G., 1997, Am J Gastroenterol, 92, 763
- Camilleri M., 1986, Gastroenterology, 91, 94, 10.1016/0016-5085(86)90444-0 · DOI
- Malagelada J.-R., 1986, Manometric diagnosis of gastrointestinal motility disorders
- Battle W.M., 1981, Ann Intern Med, 94, 749, 10.7326/0003-4819-94-6-749 · DOI
- Hamel-Roy J., 1985, Gastroenterology, 88, 1, 10.1016/S0016-5085(85)80124-4 · DOI
- Greydanus M.P., 1989, Gastroenterology, 96, 110, 10.1016/0016-5085(89)90770-1 · DOI
- Ohe M.R., 1994, Neurogastroenterol Motil, 6, 213, 10.1111/j.1365-2982.1994.tb00186.x · DOI
- Frieling T., 1996, Neurogastroenterol Motil, 8, 45, 10.1111/j.1365-2982.1996.tb00241.x · DOI
Cited by
Sorted by citations
Diabetic gastroparesis: pathophysiology and impact on insulin timing choices
Galeano, F., Tumminia, A., Oteri, V., Le Moli, R., Piticchio, T., Scilletta, S., Di Marco, M., Di Pino, A., & Frasca, F. (2026) · Endocrine · doi:10.1007/s12020-026-04693-6
“Advanced techniques, including antroduodenal-jejunal manometry [71–75], wireless motility capsule [76–79], gastric ultrasound [80–82], and high-resolution electrogas-trography (EGG) [83–87] may provide additional pathophysiological insight, particularly in complex or mixed-pattern cases.”
Metadata
- Authors
- Weston, S., Thumshirn, M., Wiste, J., & Camilleri, M.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Camilleri, Michael
- ORCID
- Camilleri, Michael
- Venue
- American Journal of Gastroenterology
- Published
- 1998-07
- Volume
- 93
- Issue
- 7
- Pages
- 1085-1089
- ISSN
- 0002-9270 (ISSN-L)
- OpenAlex
- W2082865061
- Cited by
- 186
- References
- 0
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 14 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 12 · 2015: 10 · 2014: 5 · 2013: 4 · 2012: 12
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (RR-00585, M01RR000585)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Sclerosis and Related Diseases
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- systemic sclerosis, upper gastrointestinal motility, esophageal motility, duodenal motility, esophageal aperistalsis, esophageal stricture, Barrett's metaplasia, gastroesophageal reflux disease, esophageal erosion, mixed connective tissue disease, intestinal hypomotility, pneumatosis intestinalis, dysphagia, heartburn
- MeSH terms
- Adolescent, Adult, Aged, Barrett Esophagus, Constipation, Deglutition Disorders, Diarrhea, Diverticulum, Duodenal Diseases, Duodenum, Eating, Esophageal Stenosis, Esophagogastric Junction, Esophagus, Fasting, Fecal Incontinence, Female, Gastric Emptying, Gastroesophageal Reflux, Gastrointestinal Motility, Heartburn, Humans, Male, Middle Aged, Mixed Connective Tissue Disease, Nausea, Peristalsis, Pyloric Antrum, Retrospective Studies, Scleroderma, Systemic, Vomiting, Polymyositis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
