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Cited by 226Inflammatory Bowel DiseaseOcular Diseases and Behçet’s SyndromePsychosomatic Disorders and Their Treatments

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Psychosocial Determinants of Relapse in Ulcerative Colitis: A Longitudinal Study

Bitton, Alain, Sewitch, Maida J, Peppercorn, Mark A, de B Edwardes, Michael D, Shah, Samir, Ransil, Bernard, Locke, Steven E·2003·American Journal of Gastroenterology
DOI 10.1111/j.1572-0241.2003.07717.x
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Abstract

OBJECTIVES: To determine the association between psychosocial characteristics and time to relapse in patients with inactive ulcerative colitis. METHODS: Sixty patients with clinically and endoscopically inactive ulcerative colitis were followed for 1 yr, or less if they relapsed. Demographic, psychosocial, and clinical data were obtained. Stressful life events (Psychiatric Epidemiology Research Interview Life Events Scale), psychological distress (Symptom Checklist-90R), and perceived stress (Perceived Stress Scale) were recorded monthly by self-report. Multivariate time-dependent Cox regression was used to identify the independent determinants of earlier time to clinical relapse. RESULTS: The patients' mean age was 39 yr (SD = 9.4), 37 (62%) were female, and 22 (37%) relapsed during the 1-yr follow-up. Univariate Cox regression indicated a weak association between number of stressful events in the preceding month and time to relapse (p = 0.09). This association strengthened in multivariate analysis (p = 0.02, hazard ratio = 1.26 per event, 95% CI = 1.04-1.53) after adjustment for significant covariates. CONCLUSIONS: After controlling for demographic and clinical variables, more recent stressful events were associated with earlier time to relapse. These findings, which support a biopsychosocial model of disease, might help clinicians identify patients who might benefit from more intensive maintenance medical therapy and behavioral medicine interventions to reduce stress and improve coping.

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Crossref · 10.1111/j.1572-0241.2003.07717.x

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Research works printed but not linked: 5

  1. Levenstein S., 1994, Am J Gastroenterol, 89, 1219
  2. Angelopoulos N.V., 1996, Eur J Psychiatry, 10, 87
  3. Porcelli P., 1994, Ital J Gastroenterol, 26, 111
  4. Derogatis L.R., 1994, Administration, scoring, and procedures manual
  5. Turnbull G.K., 1995, Am J Gastroenterol, 90, 1450

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Metadata

Authors
Bitton, A., Sewitch, M. J., Peppercorn, M. A., de B Edwardes, M. D., Shah, S., Ransil, B., & Locke, S. E.
Affiliations
  • McGill University (CA)
  • Université de Montréal (CA)
  • Beth Israel Deaconess Medical Center (US)
  • Harvard University (US)
Corresponding author
Bitton, Alain
ORCID
Venue
American Journal of Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-10
Volume
98
Issue
10
Pages
2203-2208
ISSN
0002-9270 (ISSN-L)
DOI
10.1111/j.1572-0241.2003.07717.x
OpenAlex
W2092717271
Cited by
226
References
26
Citations by year
2026: 4 · 2025: 2 · 2024: 12 · 2023: 4 · 2022: 14 · 2021: 10 · 2020: 9 · 2019: 12 · 2018: 17 · 2017: 7 · 2016: 5 · 2015: 11 · 2014: 7 · 2013: 9 · 2012: 14
FWCI
5.13
Type
journal article
Language
en
Open access
closed
Locations
  • The American Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r24mh056217-05)
  • National Institute of Mental Health (MH-56217)
Topics
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords
ulcerative colitis, relapse, psychosocial factors, life events, psychological distress, perceived stress, time to relapse, biopsychosocial model, maintenance therapy, behavioral medicine, coping
MeSH terms
Adult, Colitis, Ulcerative, Female, Humans, Longitudinal Studies, Male, Middle Aged, Probability, Prognosis, Prospective Studies, Psychology, Recurrence, Risk Factors, Severity of Illness Index, Stress, Psychological, Incidence, Multivariate Analysis, Proportional Hazards Models, Age Distribution, Sex Distribution

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