The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Inflammation and Coagulation in Inflammatory Bowel Disease: The Clot Thickens
Abstract
Inflammation and coagulation play crucial roles in the pathogenesis of multiple chronic inflammatory disorders. Growing evidence highlights a tight mutual network in which inflammation, coagulation, and fibrinolysis play closely related roles. Crohn's disease (CD) and ulcerative colitis (UC), the two major forms of inflammatory bowel disease (IBD), are chronic inflammatory conditions, characterized by a hypercoagulable state and prothrombotic conditions, and accompanied by abnormalities in coagulation. From a pathophysiological point of view, cells and molecules classically implicated in the physiological process of coagulation have now been shown to behave abnormally in IBD and possibly to also play an active role in disease pathogenesis and/or disease progression. This paper reviews studies performed on the coagulation profile and risk factors for thrombosis in IBD. In particular, an overview is provided of the epidemiology, clinical features, and etiology of thromboembolic complications in IBD. Furthermore, we review hemostatic abnormalities in IBD, as well as the cell types involved in such processes. Finally, we highlight the coagulation system as a dynamic participant in the multifaceted process of chronic intestinal inflammation. Overall, an overview is provided that the coagulation system represents an important, though previously underestimated, component of IBD pathogenesis, and may be a possible target for therapeutic intervention.
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Citations
Cites
Acute-Phase Proteins and Other Systemic Responses to Inflammation
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Vascular Complications of Inflammatory Bowel Disease
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PATHOGENESIS OF CROHN'S DISEASE: MULTIFOCAL GASTROINTESTINAL INFARCTION
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Is inflammatory bowel disease an independent and disease specific risk factor for thromboembolism?
Miehsler, W., Reinisch, W., Valic, E., Osterode, W., Tillinger, W., Feichtenschlager, T., Grisar, J., Machold, K., Scholz, S., Vogelsang, H., et al. (2004) · Gut · doi:10.1136/gut.2003.025411 · Cited by 479
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Self-citation
Cited by
Magro, F., Gionchetti, P., Eliakim, R., Ardizzone, S., Armuzzi, A., Barreiro-de Acosta, M., Burisch, J., Gecse, K. B., Hart, A. L., Hindryckx, P., et al. (2017) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjx008 · Cited by 1,910
Van Assche, G., Dignass, A., Reinisch, W., van der Woude, C. J., Sturm, A., De Vos, M., Guslandi, M., Oldenburg, B., Dotan, I., Marteau, P., et al. (2010) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2009.09.009 · Cited by 894
Stange, E. F., Travis, S. P. L., Vermeire, S., Reinisch, W., Geboes, K., Barakauskiene, A., Feakins, R., Fléjou, J. F., Herfarth, H., Hommes, D. W., et al. (2008) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2007.11.001 · Cited by 555
Friedman, D. J., Künzli, B. M., A-Rahim, Y. I., Sevigny, J., Berberat, P. O., Enjyoji, K., Csizmadia, E., Friess, H., & Robson, S. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902869106 · Cited by 284
Management of Iron Deficiency Anemia.
(2015) · PubMed Central · Cited by 136
Metadata
- Authors
- Danese, S., Papa, A., Saibeni, S., Repici, A., Malesci, A., & Vecchi, M.
- Venue
- The American Journal of Gastroenterology
- Published
- 2007-01
- Volume
- 102
- Issue
- 1
- Pages
- 174-186
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W2067626463
- Cited by
- 384
- References
- 77
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Danese, S., Papa, A., Saibeni, S., Repici, A., Malesci, A., & Vecchi, M. (2007). Inflammation and Coagulation in Inflammatory Bowel Disease: The Clot Thickens. The American Journal of Gastroenterology. https://doi.org/10.1111/j.1572-0241.2006.00943.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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