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Systematic Review of the Risk of Enteric Infection in Patients Taking Acid Suppression
Abstract
CONTEXT: Proton pump inhibitors (PPIs) and H(2) receptor antagonists (H(2)RAs) have become the mainstay of therapy in acid-related upper gastrointestinal disorders. There have been concerns raised about the possible association of PPIs with enteric infections. OBJECTIVE: We conducted a systematic review to evaluate any association between acid suppression and enteric infection. We also assessed differences between types of enteric infections and the type of acid suppression. DATA SOURCES: Electronic searches of MEDLINE (1966-2005), EMBASE (1988-2005), and CINAHL (1982-2005) were undertaken using a combination of subject headings and text words related to PPI therapy, H(2)RAs, and enteric infections. STUDY SELECTION: All observational studies were eligible, including cross-sectional, case control, and cohort studies that evaluated risk of enteric infection associated with antisecretory therapy. Eligibility assessment was made by two independent researchers. DATA EXTRACTION: Information on study design, patient population, type of acid suppression, type of infection, and outcomes was collected. The odds ratio (OR) of taking acid suppression therapy in cases and controls was calculated and results were synthesized using a random effects model (DerSimonian and Laird, Stats direct version 2.4.4). DATA SYNTHESIS: A total of 12 papers evaluating 2,948 patients with Clostridium difficile were included in the review. There was an increased risk of taking antisecretory therapy in those infected with C. difficile (pooled OR 1.94, 95% CI 1.37-2.75). There was significant heterogeneity between the studies (P= 0.0006) that was not explained by planned subgroup analysis. The association was greater for PPI use (OR 1.96, 95% CI 1.28-3.00) compared with H(2)RA use (OR 1.40, 95% CI 0.85-2.29). A total of six studies evaluated Salmonella, Campylobacter, and other enteric infections in 11,280 patients. There was an increased risk of taking acid suppression in those with enteric infections (OR 2.55, 95% CI 1.53-4.26). There was significant heterogeneity between the studies (P < 0.0001) that was not explained by subgroup analysis. The association was greater for PPI use (OR 3.33, 95% CI 1.84-6.02) compared with H(2)RA use (OR 2.03, 95% CI 1.05-3.92). CONCLUSION: There is an association between acid suppression and an increased risk of enteric infection. Further prospective studies on patients taking long-term acid suppression are needed to establish whether this association is causal.
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In the citing paper
“Supporting the importance of such mechanisms, a growing body of evidence has linked acid-reducing medications such as proton pump inhibitors and histamine H2 antagonists, with increased risk of enteric infections such as clostridium difficile[248–250] and profound alterations”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [249]
In the citing paper
“PPIs can influence the onset of enteric infections, resulting in an increased risk of Clostridium difficile infection (CDI), as well as Salmonella, Campylobacter and diarrheagenic Escherichia coli (E. coli)[110-113].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [112]
Citations
Cites
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Randomized, Controlled Trials, Observational Studies, and the Hierarchy of Research Designs
Concato, J., Shah, N., & Horwitz, R. I. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006223422507 · Cited by 3,563
Publication and related bias in meta-analysis
Sterne, J. A. C., Gavaghan, D., & Egger, M. (2000) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(00)00242-0 · Cited by 2,282
Loo, V. G., Poirier, L., Miller, M. A., Oughton, M., Libman, M., Michaud, S., Bourgault, A., Nguyen, T., Frenette, C. H., Kelly, M., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051639 · Cited by 1,962
Dial, S. (2005) · JAMA · doi:10.1001/jama.294.23.2989 · Cited by 954
Risk of Community-Acquired Pneumonia and Use of Gastric Acid–Suppressive Drugs
Laheij, R. J. F. (2004) · JAMA · doi:10.1001/jama.292.16.1955 · Cited by 879
Muto, C. A., Pokrywka, M., Shutt, K. A., Mendelsohn, A. B., Nouri, K., Posey, K., Roberts, T. L., Croyle, K. S., Krystoflak, S., Patel-Brown, S., et al. (2005) · Infection Control and Hospital Epidemiology · doi:10.1086/502539 · Cited by 619
Dial, S. (2004) · Canadian Medical Association Journal · doi:10.1503/cmaj.1040876 · Cited by 577
Consensus Recommendations for Managing Patients with Nonvariceal Upper Gastrointestinal Bleeding
Barkun, A. N., Bardou, M., Marshall, J. K., & for the Nonvariceal Upper GI Bleeding Consensus Conference Group* (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-10-200311180-00012 · Cited by 540
Research works printed but not linked: 4
- Laheij RJ, JAMA, 2004, 1955
- 10.1001/archinte.146.1.95 · DOI
- Gillis C, 2006, Gastroenterol, 20, 191
- Rostom A, 2002, Cochrane Database Syst Rev, 4
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Compare, D., Rocco, A., Sgamato, C., Coccoli, P., Campo, S. M. A., Nazionale, I., Larussa, T., Luzza, F., Chiodini, P., & Nardone, G. (2015) · Digestive and Liver Disease · doi:10.1016/j.dld.2015.01.004 · Cited by 15
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Wu, J. C. Y., & Tang, R. S. Y. (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s41350 · Cited by 15
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Im, J. P., Cha, J. M., Kim, J. W., Kim, S., Ryu, D. Y., Kim, E. Y., Kim, E. R., & Chang, D. K. (2014) · Gut and Liver · doi:10.5009/gnl.2014.8.3.248 · Cited by 14
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Becerra, M. G., Ospina, S., Atehortúa, S., & Fernández, D. Y. B. (2011) · Infectio · doi:10.1016/s0123-9392(11)70735-4 · Cited by 12
Walker, G. T., Yang, G., Tsai, J. Y., Rodriguez, J. L., English, B. C., Faber, F., Souvannaseng, L., Butler, B. P., & Tsolis, R. M. (2021) · Science Advances · doi:10.1126/sciadv.abd6232 · Cited by 12
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Feuerstadt, P., Allegretti, J. R., Dubberke, E. R., Guo, A. X., Harvey, A., Yang, M., García-Horton, V., Fillbrunn, M. K., Tillotson, G., Bancke, L. L., et al. (2024) · Infectious Diseases and Therapy · doi:10.1007/s40121-023-00907-w · Cited by 12
Varma, S., Trudeau, S. J., Li, J., & Freedberg, D. E. (2023) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izad035 · Cited by 12
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Linney, S., Fernandes, T., Einarson, T. R., Sengar, A., Walker, J. H., & Mills, A. (2010) · The Canadian Journal of Hospital Pharmacy · doi:10.4212/cjhp.v63i1.866 · Cited by 11
Ueberschaer, H., & Allescher, H. (2017) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0042-121265 · Cited by 11
Sieczkowska, A., Landowski, P., Gibas, A., Kamińska, B., & Lifschitz, C. H. (2017) · Journal of Breath Research · doi:10.1088/1752-7163/aa9dcf · Cited by 11
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Nachnani, J. S., Bulchandani, D. G., Moormeier, J. A., & Foxworth, J. W. (2009) · Journal of Hospital Medicine · doi:10.1002/jhm.492 · Cited by 10
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Kuo, C., Lin, C.-Y., Chen, C.-W., Hsu, C.-Y., Hsieh, S., Chiu, C., & Lin, W. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11111063 · Cited by 10
Hernández-Rocha, C., Pidal, P. C., Ajenjo, M. C., Quera, R., Quintanilla, M., Lubascher, J., Jemenao, M. I., Patricio Ibáñez, L., Álvarez-Lobos, M., Alexis Diomedi, P., et al. (2016) · Revista chilena de infectología · doi:10.4067/s0716-10182016000100020 · Cited by 10
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Fan, M., Wong, S., Yu, Q., Li, P. H., Wu, P., Chan, E. W., Wong, I. C. K., Tun, H. M., Cowling, B. J., Cheng, V. C., et al. (2023) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2023.03.013 · Cited by 9
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Hong, K. S. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i2.258 · Cited by 9
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Ströker, E., Leone, L., Vandeput, Y., Borbath, I., & Lefebvre, C. (2014) · Acta Clinica Belgica · doi:10.1179/0001551213z.0000000008 · Cited by 9
Zhou, S., Wang, S., Ma, Y., Tang, L., Shi, Y., Liang, B., Chen, Y., & Yu, K. (2016) · Hematology · doi:10.1080/10245332.2016.1142711 · Cited by 9
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Simmons, J. M., & Kotagal, U. R. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.12.017 · Cited by 9
Mir, A., Wani, Z. A., Bhat, A. R., Fahelelbom, K. M., Kumar, A., & Ahmed, S. (2024) · LabMed discovery. · doi:10.1016/j.lmd.2024.100027 · Cited by 12
Iida, K., Naiki, T., Etani, T., Nagai, T., Sugiyama, Y., Isobe, T., Aoki, M., Nozaki, S., Noda, Y., Shimizu, N., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-53158-1 · Cited by 8
Litton, E., Eastwood, G. M., Bellomo, R., Beasley, R. W., Bailey, M., Forbes, A. B., Gattas, D. J., Pilcher, D. V., Webb, S. A. R., McGuinness, S., et al. (2014) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)01466-7 · Cited by 8
Peura, D. A., & Wilcox, C. M. (2014) · Postgraduate Medicine · doi:10.3810/pgm.2014.01.2728 · Cited by 8
Zhang, L., Dong, D., Jiang, C., Xuefeng, W., & Yibing, P. (2015) · The Journal of Infection in Developing Countries · doi:10.3855/jidc.4816 · Cited by 8
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Ponder, M. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-56836-2_17 · Cited by 8
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Sáenz, J. B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.741574 · Cited by 8
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Proton pump inhibitors: concerns over prolonged use.
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Matsumoto, K., Kanazawa, N., Shigemi, A., Ikawa, K., Morikawa, N., Koriyama, T., Orita, M., Kawamura, H., Tokuda, K., Nishi, J., et al. (2014) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b14-00492 · Cited by 8
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Lanas, Á., Plazas, M. J., Gimeno, E., & Muñoz‐Tudurí, M. (2011) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2011.10.004 · Cited by 8
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Numans, M. E., de Wit, N. J., Dirven, J. A. M., Heemstra-Borst, C. G., Hurenkamp, G. B., Scheele, M., Burgers, J. S., Geijer, R. M. M., & de Jongh, E. (2013) · Pure Amsterdam UMC · Cited by 8
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Seguridad de los Inhibidores de la bomba de protones
Oscanoa, T. J. (2011) · Americanae (AECID Library) · doi:10.47892/rgp.2011.311.322 · Cited by 8
Gil, L., Martín, G., Soler, C., Vila, A., Saiz, M. R., & Navarro, P. F. (2024) · Animals · doi:10.3390/ani14081168 · Cited by 7
Zheng, Z.-L., Zheng, Q.-F., Wang, L., & Liu, Y. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i2.100589 · Cited by 9
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Bîrluțiu, V., Luca, C. M., & Bîrluţiu, R. M. (2018) · BMC Pediatrics · doi:10.1186/s12887-018-0995-0 · Cited by 7
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Abukhalil, A. D., AbuKhdeir, L., Hamed, M., Al-Shami, N. A., Naseef, H., Aiesh, B. M., & Sabateen, A. (2021) · Infection and Drug Resistance · doi:10.2147/idr.s333985 · Cited by 7
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Duffett, M., Choong, K. L. M., Foster, J. R., Gilfoyle, E., Lacroix, J., & Cook, D. J. (2017) · The Canadian Journal of Hospital Pharmacy · doi:10.4212/cjhp.v70i4.1679 · Cited by 7
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Zullo, L., Rossi, G., Dellepiane, C., Tagliamento, M., Alama, A., Coco, S., Longo, L., Pronzato, P., Maria, A. D., & Genova, C. (2021) · Immunotherapy · doi:10.2217/imt-2020-0226 · Cited by 7
Gesheff, M. G., Franzese, C. J., Bliden, K. P., Contino, C., Rafeedheen, R., Tantry, U. S., & Gurbel, P. A. (2014) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2014.945428 · Cited by 7
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Metadata
- Authors
- Leonard, J., Marshall, J. K., & Moayyedi, P.
- Affiliations
- McMaster University (CA)
- Venue
- The American Journal of Gastroenterology
- Published
- 2007-09
- Volume
- 102
- Issue
- 9
- Pages
- 2047-2056
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W2114271048
- Cited by
- 633
- References
- 46
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 22 · 2023: 24 · 2022: 32 · 2021: 35 · 2020: 39 · 2019: 29 · 2018: 35 · 2017: 41 · 2016: 30 · 2015: 28 · 2014: 30 · 2013: 63 · 2012: 55
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
- Keywords
- acid suppression, proton pump inhibitors, H2 receptor antagonists, gastrointestinal infections, Clostridium difficile infection, Salmonella, Campylobacter, Clostridium difficile-associated diarrhea, antisecretory therapy, infection risk, drug safety, Helicobacter pylori, Helicobacter heilmannii
- MeSH terms
- Bacterial Infections, Gastric Acid, Gastrointestinal Diseases, Histamine H2 Antagonists, Humans, Risk Factors, Proton Pump Inhibitors
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