The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Prophylactic Antibiotics Cannot Reduce Infected Pancreatic Necrosis and Mortality in Acute Necrotizing Pancreatitis: Evidence From a Meta-Analysis of Randomized Controlled Trials
Abstract
BACKGROUND: There is no agreement whether intravenous prophylactic antibiotics can reduce infected pancreatic necrosis and mortality in acute necrotizing pancreatitis (ANP). We performed a meta-analysis comparing intravenous antibiotics with placebo or no treatment in randomized controlled trials (RCTs). METHODS: Databases including MEDLINE, EMBASE, the Cochrane controlled trials register, the Cochrane Library, and Science Citation Index were searched to find relevant trials. Outcome measures were infected necrosis and mortality. RESULTS: Seven trials involving 467 patients were included. Analysis suggested infected pancreatic necrosis rates were not significantly different (antibiotics 17.8%, controls 22.9%), RR 0.81 (95% CI 0.54-1.22). There was nonsignificantly decreased mortality with antibiotics (9.3%) versus controls (15.2%), RR 0.70 (95% CI 0.42-1.17). Subsequent subgroup analysis confirmed antibiotics were not statistically superior to controls in reduction of infected necrosis and mortality. CONCLUSIONS: Prophylactic antibiotics cannot reduce infected pancreatic necrosis and mortality in patients with ANP.
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Moher, D., Pham, B., Jones, A., Cook, D. J., Jadad, A. R., Moher, M., Tugwell, P., & Klassen, T. P. (1998) · The Lancet · doi:10.1016/s0140-6736(98)01085-x · Cited by 3,560
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The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection
Mazuski, J. E., Tessier, J. M., May, A. K., Sawyer, R. G., Nadler, E. P., Rosengart, M. R., Chang, P. K., O'Neill, P. J., Mollen, K. P., Huston, J. M., et al. (2017) · Surgical Infections · doi:10.1089/sur.2016.261 · Cited by 573
Arvanitakis, M., Dumonceau, J.-M., Albert, J., Badaoui, A., Bali, M., Barthet, M., Besselink, M., Deviere, J., Oliveira Ferreira, A., Gyökeres, T., et al. (2018) · Endoscopy · doi:10.1055/a-0588-5365 · Cited by 538
Clinical practice guideline: management of acute pancreatitis
Greenberg, J. A., Hsu, J., Bawazeer, M., Marshall, J., Friedrich, J. O., Nathens, A., Coburn, N., May, G. R., Pearsall, E., & McLeod, R. S. (2016) · Canadian Journal of Surgery · doi:10.1503/cjs.015015 · Cited by 429
Abraha, I., Cherubini, A., Cozzolino, F., De Florio, R., Luchetta, M. L., Rimland, J. M., Folletti, I., Marchesi, M., Germani, A., Orso, M., et al. (2015) · BMJ · doi:10.1136/bmj.h2445 · Cited by 165
Metadata
- Authors
- Bai, Y., Gao, J., Zou, D.-W., & Li, Z.-S.
- Venue
- The American Journal of Gastroenterology
- Published
- 2008-01
- Volume
- 103
- Issue
- 1
- Pages
- 104-110
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W2045152698
- Cited by
- 161
- References
- 1
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Prophylactic Antibiotics Cannot Reduce Infected Pancreatic Necrosis and Mortality in Acute Necrotizing Pancreatitis: Evidence From a Meta-Analysis of Randomized Controlled Trials. https://app.cochat.ai/papers/10.1111/j.1572-0241.2007.01575.x
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- Bai, Y., Gao, J., Zou, D.-W., & Li, Z.-S. (2008). Prophylactic Antibiotics Cannot Reduce Infected Pancreatic Necrosis and Mortality in Acute Necrotizing Pancreatitis: Evidence From a Meta-Analysis of Randomized Controlled Trials. The American Journal of Gastroenterology. https://doi.org/10.1111/j.1572-0241.2007.01575.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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