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Regulation of virulence and antibiotic resistance by two-component regulatory systems in Pseudomonas aeruginosa
Abstract
The Gram-negative opportunistic pathogen Pseudomonas aeruginosa ubiquitously inhabits soil and water habitats and also causes serious, often antibiotic resistant, infections in immunocompromised patients (e.g. cystic fibrosis). This versatility is mediated in part by a large repertoire of two-component regulatory systems that appear instrumental in the regulation of both virulence processes and resistance to antimicrobials. Major two-component regulatory system proteins demonstrated to regulate these diverse processes include PhoP-PhoQ, GacA-GacS, RetS, LadS, and AlgR, among others. Here, we summarize the current body of knowledge of these and other two-component systems that provides insight into the complex regulation of virulence and resistance in P. aeruginosa.
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Cites
Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation
Drenkard, E., & Ausubel, F. M. (2002) · Nature · doi:10.1038/416740a · Cited by 997
Hassan, M.-E.-T., van der Lelie, D., Springael, D., Römling, U., Ahmed, N., & Mergeay, M. (1999) · Gene · doi:10.1016/s0378-1119(99)00349-2 · Cited by 165
Cited by
Pseudomonas aeruginosa : new insights into pathogenesis and host defenses
Gellatly, S. L., & Hancock, R. E. W. (2013) · Pathogens and Disease · doi:10.1111/2049-632x.12033 · Cited by 1,295
Self-citationEvolution of Two-Component Signal Transduction Systems
Capra, E. J., & Laub, M. T. (2012) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092611-150039 · Cited by 705
Pletzer, D., Braun, Y., & Weingart, H. (2016) · Antonie van Leeuwenhoek · doi:10.1007/s10482-016-0675-8 · Cited by 29
Ito, Y., Nakagawa, S., Komagata, A., Ikeda-Saito, M., Shiro, Y., & Nakamura, H. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.06.001 · Cited by 28
Metadata
- Authors
- Gooderham, W. J., & Hancock, R. E. W.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-03
- Volume
- 33
- Issue
- 2
- Pages
- 279-294
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W2124790912
- Cited by
- 346
- References
- 2
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gooderham, W. J., & Hancock, R. E. W. (2009). Regulation of virulence and antibiotic resistance by two-component regulatory systems in Pseudomonas aeruginosa. FEMS Microbiology Reviews. https://doi.org/10.1111/j.1574-6976.2008.00135.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
