The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Thrombospondin‐1 as an endogenous inhibitor of angiogenesis and tumor growth
Open accessAbstract
Thrombospondin‐1 (TSP‐1) is a matricellular glycoprotein that influences cellular phenotype and the structure of the extracellular matrix. These effects are important components of the tissue remodeling that is associated with angiogenesis and neoplasia. The genetic mutations in oncogenes and tumor suppressor genes that occur within tumor cells are frequently associated with decreased expression of TSP‐1. However, the TSP‐1 that is produced by stromal fibroblasts, endothelial cells and immune cells suppresses tumor progression. TSP‐1 inhibits angiogenesis through direct effects on endothelial cell migration and survival and through indirect effects on growth factor mobilization. TSP‐1 that is present in the tumor microenvironment also acts to suppress tumor cell growth through activation of transforming growth factor β in those tumor cells that are responsive to TGFβ. In this review, the molecular basis for the role of TSP‐1 in the inhibition of tumor growth and angiogenesis is summarized.
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The sequence of the human genome
Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909
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Sherman, M. H., Yu, R. T., Engle, D. D., Ding, N., Atkins, A. R., Tiriac, H., Collisson, E. A., Connor, F., Van Dyke, T., Kozlov, S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.007 · Cited by 1,158
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Anti-angiogenic therapy: current challenges and future perspectives
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Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1
Ridnour, L. A., Isenberg, J. S., Espey, M. G., Thomas, D. D., Roberts, D. D., & Wink, D. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502979102 · Cited by 323
Metadata
- Authors
- Lawler, J.
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2002-01
- Volume
- 6
- Issue
- 1
- Pages
- 1-12
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- OpenAlex
- W2081471836
- Cited by
- 540
- References
- 1
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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