The DOI matches its Crossref record; 219 of the 222 references it cites were found in a registry or an index.
Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling
Open accessAbstract
Neuronal cell death plays a role in many chronic neurodegenerative diseases with the loss of particular subsets of neurons. The loss of the neurons occurs during a period of many years, which can make the mode(s) of cell death and the initiating factors difficult to determine. In vitro and in vivo models have proved invaluable in this regard, yielding insight into cell death pathways. This review describes the main mechanisms of neuronal cell death, particularly apoptosis, necrosis, excitotoxicity and autophagic cell death, and their role in neurodegenerative diseases such as ischaemia, Alzheimer's, Parkinson's and Huntington's diseases. Crosstalk between these death mechanisms is also discussed. The link between cell death and protein mishandling, including misfolded proteins, impairment of protein degradation, protein aggregation is described and finally, some pro‐survival strategies are discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“AD is a neurodegenerative disorder marked by neuronal loss, especially in the hippocampus and cerebral cortex (49, 50).”
From Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming (2024) · cites this paper as [50]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Items 201–219 of 219
Ikonomović, M. D., Mizukami, K., Warde, D., Sheffield, R., Hamilton, R. L., Wenthold, R. J., & Armstrong, D. M. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7196 · Cited by 57
How do Parkin mutations result in neurodegeneration?
Imai, Y., & Takahashi, R. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.04.002 · Cited by 57
Glumate Receptor Dysfunction and Alzheimer's Disease
Olney, J. W., Wozniak, D. F., & Farber, N. B. (1998) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-1998-00048 · Cited by 41
Szegezdi, É., Herbert, K. R., Kavanagh, E. T., Samali, A., & Gorman, A. M. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00268.x · Cited by 41
Self-citationUpregulation of Beclin 1 in the ischemic penumbra
Rami, A. (2008) · Autophagy · doi:10.4161/auto.5339 · Cited by 37
Apoptotic morphology does not always require caspase activity in rat cerebellar granule neurons
Daré, E., Gorman, A. M., Ahlbom, E., Götz, M. E., Momoi, T., & Ceccatelli, S. (2001) · Neurotoxicity Research · doi:10.1007/bf03033206 · Cited by 36
Self-citationChen, Q., Ding, Q., Thorpe, J. A., Dohmen, R. J., & Keller, J. N. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.10.019 · Cited by 35
Heat Shock Proteins in Neural Cells
Richter‐Landsberg, C. (2009) · Springer eBooks · doi:10.1007/978-0-387-39954-6 · Cited by 35
Woodhouse, A., Dickson, T., West, A., Mclean, C., & Vickers, J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.11.010 · Cited by 34
Mutant huntingtin can paradoxically protect neurons from death
Züchner, T., & Brundin, P. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402261 · Cited by 30
Ubiquitin-Proteasome Pathway Components as Therapeutic Targets for CNS Maladies
Upadhya, S. C., & Hegde, A. (2005) · Current Pharmaceutical Design · doi:10.2174/138161205774580651 · Cited by 26
Alpha-synuclein overexpression model.
Mochizuki, H., YAMADA, M., & Mizuno, Y. (2006) · PubMed · Cited by 25
Gene therapy for Parkinson’s disease
Mochizuki, H., & Mizuno, Y. (2003) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-0643-3_13 · Cited by 24
α-Synuclein overexpression model
Mochizuki, H., YAMADA, M., & Mizuno, Y. (2006) · Springer eBooks · doi:10.1007/978-3-211-45295-0_44 · Cited by 21
McNaught, K. S. P., & Olanow, C. W. (2009) · Annals of Neurology · doi:10.1002/ana.21662 · Cited by 14
Gene therapy for Parkinson’s disease
Mochizuki, H. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.8.957 · Cited by 12
Heat Shock Proteins and the Regulation of Apoptosis
FitzGerald, U., Gorman, A. M., & Afshin Samali, A. (2009) · Springer eBooks · doi:10.1007/978-0-387-39954-6_5 · Cited by 8
Self-citationHeat shock protein 70 alters the endosome-lysosomal localization of huntingtin
Kang, B. S., Ahn, J., Kim, M. K., Kim, H. J., Kang, L., Lim, H.-C., Park, K.-S., Lee, J., Seo, J., Ik, C., et al. (2007) · Experimental & Molecular Medicine · doi:10.1038/emm.2007.5 · Cited by 5
Research works printed but not linked: 1
- 10.1002/(SICI)1096-9861(19970203)378:1<10::AID-CNE4>3.0.CO;2-N · DOI
Cited by
Sorted by citations
Cellular Stress Responses: Cell Survival and Cell Death
Fulda, S., Gorman, A. M., Hori, O., & Samali, A. (2010) · International Journal of Cell Biology · doi:10.1155/2010/214074 · Cited by 1,590
Self-citationMolecular mechanisms of cell death in neurological diseases
Moujalled, D., Strasser, A., & Liddell, J. R. (2021) · Cell Death & Differentiation · doi:10.1038/s41418-021-00814-y · Cited by 749
Basic mechanisms of neurodegeneration: a critical update
Jellinger, K. A. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01010.x · Cited by 640
Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums
Ravichandran, K. S. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101157 · Cited by 572
Cohen, R. M., Rezai-Zadeh, K. P., Weitz, T. M., Rentsendorj, A., Gate, D., Spivak, I. E., Bholat, Y., Vasilevko, V., Glabe, C. G., Breunig, J. J., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3672-12.2013 · Cited by 555
Metadata
- Authors
- Gorman, A. M.
- Affiliations
- Ollscoil na Gaillimhe – University of Galway (IE)
- Corresponding author
- Gorman, Adrienne M.
- ORCID
- Gorman, Adrienne M.
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2008-07-10
- Volume
- 12
- Issue
- 6a
- Pages
- 2263-2280
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- PMC
- PMC4514105
- OpenAlex
- W1965453486
- Cited by
- 362
- References
- 222
- Citations by year
- 2026: 18 · 2025: 28 · 2024: 35 · 2023: 34 · 2022: 38 · 2021: 36 · 2020: 11 · 2019: 26 · 2018: 28 · 2017: 26 · 2016: 11 · 2015: 6 · 2014: 8 · 2013: 9 · 2012: 10
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Cellular and Molecular Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Research Repository UCD (University College Dublin) (cc-by)
- Funders
- National University of Ireland
- University of Galway
- Irish Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neuronal cell death, neurodegenerative diseases, apoptosis, necrosis, excitotoxicity, autophagic cell death, protein misfolding, protein aggregation, protein degradation, ischemia, Alzheimer's disease, Parkinson's disease, Huntington's disease, neuroprotection
- MeSH terms
- Alzheimer Disease, Autophagy, Brain Ischemia, Endoplasmic Reticulum, Humans, Huntington Disease, Models, Neurological, Necrosis, Nerve Tissue Proteins, Neurons, Parkinson Disease, Stress, Physiological, Receptors, N-Methyl-D-Aspartate, Cell Death, Apoptosis, Neurodegenerative Diseases, Ubiquitin, Proteasome Endopeptidase Complex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
