The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
Endogenous toll‐like receptor ligands and their biological significance
Open accessAbstract
Introduction TLR signalling Endogenous TLR ligands Biological significance of signalling triggered by endogenous TLR ligands Conclusions Toll‐like receptors (TLRs), a family of pattern recognition receptors, recognize and respond to conserved components of microbes and play a crucial role in both innate and adaptive immunity. In addition to binding exogenous ligands derived from pathogens, TLRs interact with endogenous molecules released from damaged tissues or dead cells and regulate many sterile inflammation processes. Putative endogenous TLR ligands include proteins and peptides, polysaccharides and proteoglycan, nucleic acids and phospholipids, which are cellular components, particularly extracellular matrix degradation products. Accumulating evidence demonstrates that endogenous ligand‐mediated TLR signalling is involved in pathological conditions such as tissue injury, repair and regeneration; autoimmune diseases and tumorigenesis. The ability of TLRs to recognize endogenous stimulators appears to be essential to their function in regulating non‐infectious inflammation. In this review, we summarize current knowledge of endogenous TLR ligands and discuss the biological significance of TLR signalling triggered by endogenous ligands in several sterile inflammation conditions.
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DAMP-sensing receptors in sterile inflammation and inflammatory diseases
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Toll-like receptors in the pathogenesis of neuroinflammation
Kumar, V. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.03.012 · Cited by 331
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DAMPs as mediators of sterile inflammation in aging-related pathologies
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Metadata
- Authors
- Yu, L., Wang, L., & Chen, S.
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2010-11
- Volume
- 14
- Issue
- 11
- Pages
- 2592-2603
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- OpenAlex
- W2028491403
- Cited by
- 532
- References
- 158
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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