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The psychiatric comorbidity of epilepsy

Gaitatzis, A., Trimble, M. R., Sander, J. W.·2004·Acta Neurologica Scandinavica

Abstract

Several studies have assessed the prevalence of psychiatric disorders in epilepsy. They are characterized by considerable heterogeneity, because of differences in the population setting and type of study. A non-systematic review of the literature allows us to draw some useful, although not definite, conclusions. Six per cent of people with epilepsy in the general population appear to suffer from a psychiatric disorder, while this rises to 10-20% in populations with temporal lobe and/or refractory epilepsy. Mood disorders are the most common culprit (24-74%), particularly depression (30%), followed by anxiety disorders (10-25%), psychoses (2-7%) and personality disorders (1-2%). This comorbidity appears to be related to endogenous and exogenous (including iatrogenic) factors and to the severity and chronicity of epilepsy. Conditions such as schizophrenia-like psychosis of epilepsy and interictal dysphoric disorder are represented only in epilepsy. Adequate recognition and treatment of psychiatric conditions in epilepsy is essential for patient management because of their considerable burden in morbidity and quality of life.

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Metadata

Authors
Gaitatzis, A., Trimble, M. R., & Sander, J. W.
Venue
Acta Neurologica Scandinavica
Publisher
Wiley
Published
2004-10
Volume
110
Issue
4
Pages
207-220
ISSN
  • 0001-6314 (ISSN-L)
  • 1600-0404
OpenAlex
W2168014711
Cited by
581
References
5
FWCI
9.84
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The psychiatric comorbidity of epilepsy. https://app.cochat.ai/papers/10.1111/j.1600-0404.2004.00324.x
The paper
Gaitatzis, A., Trimble, M. R., & Sander, J. W. (2004). The psychiatric comorbidity of epilepsy. Acta Neurologica Scandinavica. https://doi.org/10.1111/j.1600-0404.2004.00324.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.