The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Formulation of a drug delivery system based on a mixture of monoglycerides and triglycerides for use in the treatment of periodontal disease
Abstract
Abstract. This paper describes the development of a stable, controlled‐release formulation of metronidazole for use in the treatment of periodontal disease. It is formulated as a suspension, which undergoes transformation to a release‐controlling, semi‐solid on contact with gingival fluid. The system is based on the ability of mixtures of monoglycerides and triglycerides to form liquid crystals, i.e., reversed hexagonals, in contact with water. The reversed hexagonal form was found to have the most favourable sustained release properties, compared with those from the cubic form. The source of metronidazole is the prodrug, metronidazole benzoate, which further helps to slow down the release rate. Product characteristics are assessed by differential scanning calorimetry and viscometry. The release data derive from the results of in vitro dissolution tests. X‐ray diffraction, phase diagrams, and polarized light microscopy were used to elucidate the structure of the liquid crystalline phases.
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Citations
Cites
Experimental gingivitis in man
Löe, H., Theilade, E., & Jensen, S. B. (1965) · The Journal of Periodontology · doi:10.1902/jop.1965.36.3.177 · Cited by 3,481
Cited by
Antibiotic-eluting medical devices for various applications
ZILBERMAN, M., & ELSNER, J. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.05.020 · Cited by 610
Bioadhesive drug delivery systems
Nielsen, L. S., Schubert, L., & Hansen, J. (1998) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(97)10004-5 · Cited by 403
Oliveira, M. B., Prado, A. H. D., Bernegossi, J., Sato, C. S., Lourenço Brunetti, I., Scarpa, M. V., Leonardi, G. R., Friberg, S. E., & Chorilli, M. (2014) · BioMed Research International · doi:10.1155/2014/632570 · Cited by 49
Metadata
- Authors
- Norling, T., Lading, P., Engström, S., Larsson, K., Krog, N., & Nissen, S. S.
- Venue
- Journal of Clinical Periodontology
- Publisher
- Wiley
- Published
- 1992-10
- Volume
- 19
- Issue
- 9
- Pages
- 687-692
- ISSN
- 0303-6979 (ISSN-L)
- 1600-051X
- OpenAlex
- W2027364164
- Cited by
- 166
- References
- 1
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Formulation of a drug delivery system based on a mixture of monoglycerides and triglycerides for use in the treatment of periodontal disease. https://app.cochat.ai/papers/10.1111/j.1600-051x.1992.tb02529.x
- The paper
- Norling, T., Lading, P., Engström, S., Larsson, K., Krog, N., & Nissen, S. S. (1992). Formulation of a drug delivery system based on a mixture of monoglycerides and triglycerides for use in the treatment of periodontal disease. Journal of Clinical Periodontology. https://doi.org/10.1111/j.1600-051x.1992.tb02529.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
