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Cited by 67

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Infections and serum IgG levels in patients with chronic lymphocytic leukemia

Itala, M., Helenius, H., Nikoskelainen, J., Remes, K.·1992·European Journal of Haematology
DOI 10.1111/j.1600-0609.1992.tb01805.x
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Abstract

Abstract: To review our policy of prophylactic treatment with intravenous immunoglobulin (i.v.IG) in chronic lymphocytic leukemia (CLL), we analyzed the infection history, serum IgG levels (S‐IgG) and disease stage of 146 patients who were treated and followed at our institution in 1980–1989. S‐IgG was available for 98 patients: 55% were hypogammaglobulinemic and 56% had had at least one severe infection. There were significant associations between S‐IgG and the occurrence of infections (p<0.01) and disease stage (p < 0.02). There was also a significant association between disease stage and occurrence of infections (p< 0.001). Severe infections tended to accumulate in patients with subnormal S‐IgG and advanced disease stage. Totally, 292 infections were recorded, and the incidence of moderate to severe infections was 0.47 per patient year. Infection mortality was high: 42 patients died of a severe infection (46% of all causes of death). Patients with a low S‐IgG and advanced disease stage are the most susceptible to death from infection and would be most likely to benefit most from i.v.IG prophylaxis; however, the cost of this therapy is so high that strict individual consideration still remains crucial for treatment decisions.

Overview

Integrity signals

Registry

Crossref · 10.1111/j.1600-0609.1992.tb01805.x

Cites

19 of 19 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 3

  1. Dixon WJ, 1990, BMDP Statistical Software Manual, 1
  2. Brown RK, 1948, Elec‐trophoretic analysis of serum proteins of the blood dyscra‐sias, J Lab Clin Med, 33, 1523
  3. Editorial, 1990, Consensus on IVIG, Lancet, 470

Cited by

See all 67

Metadata

Authors
Itala, M., Helenius, H., Nikoskelainen, J., & Remes, K.
Venue
European Journal of Haematology
Publisher
Wiley
Published
1992-05
Volume
48
Issue
5
Pages
266-270
ISSN
  • 0902-4441
  • 1600-0609
DOI
10.1111/j.1600-0609.1992.tb01805.x
Cited by
67
References
19
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6202 d)

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.