The other pigment cell: specification and development of the pigmented epithelium of the vertebrate eye
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Summary: Vertebrate retinal pigment epithelium (RPE) cells are derived from the multipotent optic neuroepithelium, develop in close proximity to the retina, and are indispensible for eye organogenesis and vision. Recent advances in our understanding of RPE development provide evidence for how critical signaling factors operating in dorso‐ventral and distal‐proximal gradients interact with key transcription factors to specify three distinct domains in the budding optic neuroepithelium: the distal future retina, the proximal future optic stalk/optic nerve, and the dorsal future RPE. Concomitantly with domain specification, the eye primordium progresses from a vesicle to a cup, RPE pigmentation extends towards the ventral side, and the future ciliary body and iris form from the margin zone between RPE and retina. While much has been learned about the molecular networks controlling RPE cell specification, key questions concerning the cell proliferative parameters in RPE and the subsequent morphogenetic events still need to be addressed in greater detail.
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The RPE develops from the eye primordium and is continuous with the layer of cells that forms the iris.
“The RPE develops from the eye primordium, and is continuous with the layer of cells that forms the iris [31].”
In addition to neural-crest-derived chromatophores, another population of pigment cells forms the retinal pigment epithelium and originates from optic lobe neuroepithelial cells.
“In addition to these three populations, which in zebrafish larvae derive from neural crest cells, there is another population of pigment cells forming the retinal pigment epithelium (RPE), which originates from optic lobe neuroepithelial cells (Fig. 1a)7.”
From A crystal-clear zebrafish for in vivo imaging (2016) · cites this paper as [7]
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Zhao, C., Yasumura, D., Li, X., Matthes, M., Lloyd, M., Nielsen, G., Ahern, K., Snyder, M., Bok, D., Dunaief, J. L., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44303 · Cited by 303 · see citing works
A crystal-clear zebrafish for in vivo imaging
Antinucci, P., & Hindges, R. (2016) · Scientific Reports · doi:10.1038/srep29490 · Cited by 165 · see citing works
Higdon, C. W., Mitra, R. D., & Johnson, S. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067801 · Cited by 125 · see citing works
- Authors
- Bharti, K., Nguyen, M. T., Skuntz, S., Bertuzzi, S., & Arnheiter, H.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Arnheiter, Heinz
- Venue
- Pigment Cell Research
- Publisher
- Wiley
- Published
- 2006-05-24
- Volume
- 19
- Issue
- 5
- Pages
- 380-394
- ISSN
- 0893-5785 (ISSN-L)
- 1600-0749
- PMC
- PMC1564434
- OpenAlex
- W2050991107
- Cited by
- 237
- References
- 1
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 15 · 2023: 11 · 2022: 16 · 2021: 21 · 2020: 22 · 2019: 12 · 2018: 10 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 9 · 2013: 14 · 2012: 12
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pigment Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Institutes of Health (1z01ns002790-06)
- National Institute of Neurological Disorders and Stroke (Z01 NS002790-17)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Ocular Disorders and Treatments
- Keywords
- retinal pigment epithelium, transcription factors, optic stalk, optic nerve, eye primordium, ciliary body, iris, cell proliferation, morphogenesis
- MeSH terms
- Animals, Cell Differentiation, Humans, Optic Nerve, Pigment Epithelium of Eye, Pigmentation, Retina, Signal Transduction, Gene Expression Regulation, Developmental, Mice
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