Periodontal innate immune mechanisms relevant to atherosclerosis and obesity: Influence of periodontal disease on obesity and atherosclerosis
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Obese ATMs produce high levels of TNFα, IL-6, and IL-1β, also elevated in insulin resistant individuals.
“These cells produce high levels of TNFα, IL-6, and IL-1β, all of which are also observed in increased levels of adipose tissue from insulin resistant individuals.”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [69]
Periodontal disease has mechanistic parallels and links to atherosclerosis and obesity.
“Importantly, periodontal disease has been shown to have many mechanistic parallels and links to the pathogenic processes of atherosclerosis and obesity [69].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [69]
In obesity, ATMs have a strongly polarized pro-inflammatory M1 phenotype.
“While the ATMs present in healthy lean adipose tissue are primarily of an M2 phenotype, those that accumulate in the adipose tissue during obesity have a strongly polarized pro-inflammatory, M1 phenotype [63,69–71].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [69]
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References 131 · Cited by 81
Research works printed but not linked: 5
- [23]Chandra RK Au B Spleen hemolytic plaque-forming cell response and generation of cytotoxic cells in genetically obese (C57Bl/6J ob/ob) mice Int Arch Allergy Appl Immunol 1980 62 94 98 6989763
- [38]Epstein SE Zhou YF Zhu J Infection and atherosclerosis: emerging mechanistic paradigms Circulation 1999 100 e20 28 10421626
- [70]Loppnow H Werdan K Buerke M Vascular cells contribute to atherosclerosis by cytokine- and innate-immunity-related inflammatory mechanisms Innate Immun 2008 14 63 87 18713724
- [100]Ryan AM Healy LA Power DG Byrne M Murphy S Byrne PJ Kelleher D Reynolds JV Barrett esophagus: prevalence of central adiposity, metabolic syndrome, and a proinflammatory state Ann Surg 2008 247 909 915 18520215
- [128]Zhu J Quyyumi AA Norman JE Csako G Epstein SE Cytomegalovirus in the pathogenesis of atherosclerosis: the role of inflammation as reflected by elevated C-reactive protein levels J Am Coll Cardiol 1999 34 1738 1743 10577564
- Authors
- Zelkha, S. A., Freilich, R. W., & Amar, S.
- Affiliations
- Boston University (US)
- Venue
- Periodontology 2000
- Publisher
- Wiley
- Published
- 2010-08-16
- Volume
- 54
- Issue
- 1
- Pages
- 207-221
- ISSN
- 0906-6713 (ISSN-L)
- PMC
- PMC2928057
- OpenAlex
- W2171942854
- Cited by
- 81
- References
- 131
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 9 · 2017: 5 · 2016: 10 · 2015: 7 · 2014: 6 · 2013: 7 · 2012: 6
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Periodontology 2000 (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Touro Scholar (Touro College) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL076801)
- National Institute of Dental and Craniofacial Research (R01DE015989, R01DE015345)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- atherosclerosis, obesity, periodontitis, host defense
- MeSH terms
- Animals, Endothelium, Vascular, Humans, Immune Tolerance, Immunity, Innate, Inflammation, Macrophages, Obesity, Periodontitis, Porphyromonas gingivalis, Atherosclerosis, Toll-Like Receptors, Nod Signaling Adaptor Proteins
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