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On the Effect of a Polypeptide Isolated from “Kalata‐Kalata” (Oldenlandia affinis DC) on the Oestrogen Dominated Uterus
Abstract
Abstract: In African folk medicine an aqueous extract of Oldenlandia affinis DC, “Kalata‐Kalata”, is used to accelerate childbirth. From the extract, which induced strong contractions in isolated uteri, serotonin and an utero‐active polypeptide have been isolated. The peptide has been examined on oestrogen dominated uteri from rats and rabbits in vivo and in vitro and also on human, uterine strips. The oxytocic activity showed the same threshold value of 20 üg/ml in vitro for all three species. In vivo the same dose caused ventricular fibrillation.
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Citations
Cited by
Colgrave, M. L., & Craik, D. J. (2004) · Biochemistry · doi:10.1021/bi049711q · Cited by 580
Orally Absorbed Cyclic Peptides
Nielsen, D. S., Shepherd, N. E., Xu, W., Lucke, A. J., Stoermer, M. J., & Fairlie, D. P. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00838 · Cited by 445
Circular proteins — no end in sight
Trabi, M., & Craik, D. J. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02057-1 · Cited by 255
Chemical Synthesis of Circular Proteins
Tam, J. P., & Wong, C. T. T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.323568 · Cited by 172
Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design
Koehbach, J., O’Brien, M., Muttenthaler, M., Miazzo, M., Akcan, M., Elliott, A. G., Daly, N. L., Harvey, P. J., Arrowsmith, S., Gunasekera, S., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311183110 · Cited by 155
Metadata
- Authors
- Gran, L.
- Venue
- Acta Pharmacologica et Toxicologica
- Publisher
- Wiley
- Published
- 1973-11
- Volume
- 33
- Issue
- 5-6
- Pages
- 400-408
- ISSN
- 0001-6683 (ISSN-L)
- OpenAlex
- W2043981733
- Cited by
- 229
- References
- 0
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: On the Effect of a Polypeptide Isolated from “Kalata‐Kalata” (Oldenlandia affinis DC) on the Oestrogen Dominated Uterus. https://app.cochat.ai/papers/10.1111/j.1600-0773.1973.tb01541.x
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- Gran, L. (1973). On the Effect of a Polypeptide Isolated from “Kalata‐Kalata” (Oldenlandia affinis DC) on the Oestrogen Dominated Uterus. Acta Pharmacologica et Toxicologica. https://doi.org/10.1111/j.1600-0773.1973.tb01541.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
