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Sodium N‐Methyl‐D‐glucamine Dithiocarbamate and Cadmium Intoxication
Abstract
Abstract: The sodium and ammonium salts of N‐methyl‐D‐glucamine dithiocarbamate were prepared and their usefulness as antidotes for cadmium intoxication investigated. This chelating agent was found to be effective in both acute and repeated exposure cadmium poisoning. A single intraperitoneal injection of sodium N‐methyl‐D‐glucamine dithiocarbamate (NaNMG‐DTC), administered at a level greater than 1.1 mmol/kg body weight, protects against a normally lethal (>95%) dose of cadmium chloride (10 mg CdCl 2/kg body weight) and results in a subsequent dose‐dependent decrease in the liver and kidney burdens of cadmium ion. In repeated exposure cadmium intoxication, repeated administration of NaNMG‐DTC can result in substantial reductions in both the kidney (71%) and the liver (40%) levels of cadmium. The LD50 of the compound was not determined, but single injections of 26.6 mmol/kg body weight (injectate volume 1.0 ml) are well tolerated in mice.
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Citations
Cited by
Enzyme-independent formation of nitric oxide in biological tissues
Zweier, J. L., Wang, P., Samouilov, A., & Kuppusamy, P. (1995) · Nature Medicine · doi:10.1038/nm0895-804 · Cited by 788
Nagano, T., & Yoshimura, T. (2002) · Chemical Reviews · doi:10.1021/cr010152s · Cited by 414
Non-Enzymatic Nitric Oxide Synthesis in Biological Systems
Zweier, J. L., Samouilov, A., & Kuppusamy, P. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00018-3 · Cited by 363
Characterization of the Magnitude and Kinetics of Xanthine Oxidase-catalyzed Nitrite Reduction
Li, H., Samouilov, A., Liu, X., & Zweier, J. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011648200 · Cited by 280
Nitric Oxide Production from Nitrite Occurs Primarily in Tissues Not in the Blood
Li, H., Cui, H., Kundu, T. K., Alzawahra, W., & Zweier, J. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801785200 · Cited by 269
Metadata
- Authors
- Shinobu, L. A., Jones, S. G., & Jones, M. M.
- Venue
- Acta Pharmacologica et Toxicologica
- Publisher
- Wiley
- Published
- 1984-03
- Volume
- 54
- Issue
- 3
- Pages
- 189-194
- ISSN
- 0001-6683 (ISSN-L)
- OpenAlex
- W2035929028
- Cited by
- 220
- References
- 0
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shinobu, L. A., Jones, S. G., & Jones, M. M. (1984). Sodium N‐Methyl‐D‐glucamine Dithiocarbamate and Cadmium Intoxication. Acta Pharmacologica et Toxicologica. https://doi.org/10.1111/j.1600-0773.1984.tb01916.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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