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Cited by 44

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Experimentally Induced Lipid Peroxidation after Exposure to Chromium, Mercury or Silver: Interactions with Carbon Tetrachloride

Rungby, Jorgen, Ernst, Erik·1992·Pharmacology & Toxicology
DOI 10.1111/j.1600-0773.1992.tb00458.x
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Abstract

Abstract: Chromium, along with other heavy metals, induces an increased production of malondialdehyde (MDA), an indicator of lipid peroxidation, in liver and kidney tissue of NMRI male mice. After acute intoxications MDA levels remain high for 60 min. and thereafter return to normal in the kidney whereas MDA levels in liver are still increased 48 hr after exposure. Exposure of mice to chromium, mercury, or silver and another stimulator of lipid peroxidation, carbon tetrachloride, showed synergism between inorganic mercury and CCl 4. Pre‐exposure to chromium, organic mercury, or silver at selected doses did not enhance CCl 4‐toxicity as measured by organ content of MDA.

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Research works printed but not linked: 17

  1. 10.1016/0378-4274(88)90063-X · DOI
  2. 10.1016/0041-008X(86)90331-5 · DOI
  3. 10.1016/0041-008X(84)90091-7 · DOI
  4. Garcia J. D., 1981, Electron transport cytochrome P‐450 system is involved in the microsomal metabolism of the carcinogen chromate, J. Inorg. Chem., 14, 281
  5. Harish G., 1985, Studies on tissue distribution of glutathione and on activities of glutathione‐related enzymes after carbon tetrachloride‐induced liver injury, Res. Comm. Chem. Pathol. Pharmacol., 47, 399
  6. 10.1016/0041-008X(83)90179-5 · DOI
  7. 10.1016/B978-0-12-642760-8.50016-8 · DOI
  8. 10.1016/0006-2952(71)90253-X · DOI
  9. 10.1016/0300-483X(88)90226-0 · DOI
  10. 10.1016/0003-2697(79)90738-3 · DOI
  11. 10.1016/0300-483X(87)90099-0 · DOI
  12. 10.1007/BF00316206 · DOI
  13. Samitz M. H., 1970, Ascorbic acid in the prevention and treatment of toxic effects from chromates, Acta dermatovener, 50, 59
  14. 10.1042/bj1230805 · DOI
  15. 10.1016/0041-008X(82)90023-0 · DOI
  16. 10.1016/0006-2952(81)90576-1 · DOI
  17. 10.1248/cpb.30.1437 · DOI

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Metadata

Authors
Rungby, J., & Ernst, E.
Venue
Pharmacology & Toxicology
Publisher
Wiley
Published
1992-03
Volume
70
Issue
3
Pages
205-207
ISSN
0901-9928
DOI
10.1111/j.1600-0773.1992.tb00458.x
Cited by
44
References
0
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6233 d)

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