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Proteomic-Based Identification of Cleaved Urinary β2-microglobulin as a Potential Marker for Acute Tubular Injury in Renal Allografts
Open accessAbstract
Our aim is to develop noninvasive tests to monitor the renal allograft posttransplant. Previously, we have reported that an unbiased proteomic-based approach can detect urine protein peaks associated with acute tubulointerstitial renal allograft rejection. Identification of these proteins peaks by mass spectrometry demonstrated that they all derive from nontryptic cleaved forms of beta2-microglobulin. In vitro experiments showed that cleavage of intact beta2-microglobulin requires a urine pH < 6 and the presence of aspartic proteases. Patients with acute tubulointerstitial rejection had lower urine pH than stable transplants and healthy individuals. In addition, they had higher amounts of aspartic proteases and intact beta2-microglobulin in urine. These factors ultimately lead to increased amounts of cleaved urinary beta2-microglobulin. Cleaved beta2-microglobulin as an indicator of acute tubular injury may become a useful tool for noninvasive monitoring of renal allografts.
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Citations
Cited by
Biomarkers of Acute Kidney Injury
Vaidya, V. S., Ferguson, M. A., & Bonventre, J. V. (2008) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.48.113006.094615 · Cited by 729
Rediscovering Beta-2 Microglobulin As a Biomarker across the Spectrum of Kidney Diseases
Argyropoulos, C. P., Chen, S. S., Ng, Y.-H., Roumelioti, M.-E., Shaffi, K., Singh, P. P., & Tzamaloukas, A. H. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00073 · Cited by 308
Clinical proteomics: A need to define the field and to begin to set adequate standards
Mischak, H., Apweiler, R., Banks, R. E., Conaway, M., Coon, J., Dominiczak, A., Ehrich, J. H. H., Fliser, D., Girolami, M., Hermjakob, H., et al. (2007) · PROTEOMICS – Clinical Applications · doi:10.1002/prca.200600771 · Cited by 307
Advances in Urinary Proteome Analysis and Biomarker Discovery
Fliser, D., Novak, J., Thongboonkerd, V., Argile[Combining Acute Accent]s, A. G. A., Jankowski, V., Girolami, M. A., Jankowski, J., & Mischak, H. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006090956 · Cited by 286
Biomarkers of Drug-Induced Kidney Toxicity
Griffin, B. R., Faubel, S., & Edelstein, C. L. (2019) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000000589 · Cited by 285
Metadata
- Authors
- Schaub, S., Wilkins, J. A., Antonovici, M., Krokhin, O., Weiler, T., Rush, D., & Nickerson, P.
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 5
- Issue
- 4
- Pages
- 729-738
- ISSN
- 1600-6135 (ISSN-L)
- OpenAlex
- W1988875944
- Cited by
- 203
- References
- 0
- FWCI
- 13.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Proteomic-Based Identification of Cleaved Urinary β2-microglobulin as a Potential Marker for Acute Tubular Injury in Renal Allografts. https://app.cochat.ai/papers/10.1111/j.1600-6143.2005.00766.x
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- Schaub, S., Wilkins, J. A., Antonovici, M., Krokhin, O., Weiler, T., Rush, D., & Nickerson, P. (2005). Proteomic-Based Identification of Cleaved Urinary β2-microglobulin as a Potential Marker for Acute Tubular Injury in Renal Allografts. American Journal of Transplantation. https://doi.org/10.1111/j.1600-6143.2005.00766.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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