Does the Permanent Portacaval Shunt for a Small-for-Size Graft in a Living Donor Liver Transplantation Do More Harm Than Good?
Open accessAbstract
In order to obviate a small-for-size graft syndrome (SFSGS), a portacaval (PC) shunt had been considered in a case of adult-to-adult living donor liver transplantation (AA-LDLT). In a recent AA-LDLT case, we adopted the PC shunt to resolve SFSGS; however, graft atrophy was observed in the late period of LDLT, thereby resulting in liver dysfunction. Due to the surgical closure of the PC shunt at 11 months post-LDLT, the graft regenerated gradually and resulted in the recovery of the liver function. This experience indicates that the portacaval shunt would overcome SFSGS in the early period of LDLT, while it would cause the graft atrophy and the graft dysfunction in the late period of LDLT.
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Liver regeneration slows down if hepatectomy is performed after portocaval shunting.
“Additionally, studies have shown that LR slows down if hepatectomy is performed after portocaval shunting[38,39].”
From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [39]
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Liver regeneration after partial hepatectomy: Triggers and mechanisms
Korchilava, B., Khachidze, T., Megrelishvili, N., Svanadze, L., Kakabadze, M., Tsomaia, K., Jintcharadze, M., & Kordzaia, D. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i7.107378 · Cited by 21 · see citing works
- Authors
- Oura, T., Taniguchi, M., Shimamura, T., Suzuki, T., Yamashita, K., Uno, M., Goto, R., Watanabe, M., Kamiyama, T., Matsushita, M., Furukawa, H., & Todo, S.
- Affiliations
- Hokkaido University (JP)
- Corresponding author
- Todo, S.
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 8
- Issue
- 1
- Pages
- 250-252
- ISSN
- 1600-6135 (ISSN-L)
- OpenAlex
- W1922858099
- Cited by
- 42
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2020: 2 · 2019: 3 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 3
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- American Journal of Transplantation (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Keywords
- portacaval shunt, small-for-size graft, living donor liver transplantation, adult-to-adult living donor, graft atrophy, graft dysfunction, graft regeneration, liver function recovery
- MeSH terms
- Adult, Atrophy, Female, Humans, Liver, Liver Function Tests, Male, Organ Size, Portacaval Shunt, Surgical, Syndrome, Liver Transplantation, Living Donors
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