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Cited by 148

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Sirolimus May Reduce Fertility in Male Renal Transplant Recipients

Zuber, J., Anglicheau, D., Elie, C., Bererhi, L., Timsit, M-O., Mamzer-Bruneel, M-F., Ciroldi, M., Martinez, F., Snanoudj, R., Hiesse, C., Kreis, H., Eustache, F., Laborde, K., Thervet, E., Legendre, C.·2008·American Journal of Transplantation
DOI 10.1111/j.1600-6143.2008.02267.x
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  • Another side effect of doses of rapamycin that extend lifespan in mice is testicular degeneration, and reduced male fertility has been observed in humans treated with rapalogs.

    “Another side effect of doses of rapamycin that extend lifespan in mice is testicular degeneration 25,144, and reduced male fertility has been observed in humans treated with rapalogs 145,146.”

    From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [145]

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Research works printed but not linked: 26

  1. Haberman, 1991, Male fertility in cyclosporine-treated renal transplant patients, J Urol, 145, 294, 10.1016/S0022-5347(17)38318-0 · DOI
  2. Handelsman, 1984, Testicular function after renal transplantation: Comparison of Cyclosporin A with azathioprine and prednisone combination regimes, Clin Nephrol, 22, 144
  3. Holdsworth, 1977, The pituitary-testicular axis in men with chronic renal failure, N Engl J Med, 296, 1245, 10.1056/NEJM197706022962201 · DOI
  4. Holdsworth, 1978, A comparison of hemodialysis and transplantation in reversing the uremic disturbance of male reproductive function, Clin Nephrol, 10, 146
  5. Lim, 1975, Gonadal dysfunction in uremic men. A study of the hypothalamo-pituitary-testicular axis before and after renal transplantation, Am J Med, 58, 655, 10.1016/0002-9343(75)90501-X · DOI
  6. Palmer, 1999, Sexual dysfunction in uremia, J Am Soc Nephrol, 10, 1381, 10.1681/ASN.V1061381 · DOI
  7. Prem, 1996, Male reproductive function in uraemia: Efficacy of haemodialysis and renal transplantation, Br J Urol, 78, 635, 10.1046/j.1464-410X.1996.14624.x · DOI
  8. Eid, 1996, Assessment of sperm motion characteristics in infertile renal transplant recipients using computerized analysis, Int J Androl, 19, 338, 10.1111/j.1365-2605.1996.tb00524.x · DOI
  9. Armenti, 2006, Report from the National Transplantation Pregnancy Registry: Outcomes of Pregnancy After Transplantation Terasaki Foundation Laboratory (ed.), 57
  10. McKay, 2005, Reproduction and transplantation: Report on the AST Consensus Conference on Reproductive Issues and Transplantation, Am J Transplant, 5, 1592, 10.1111/j.1600-6143.2005.00969.x · DOI
  11. Bererhi, 2003, Rapamycin-induced oligospermia, Transplantation, 76, 885, 10.1097/01.TP.0000079830.03841.9E · DOI
  12. Boobes, 2007, High incidence of infertility in men and women kidney transplant patients receiving sirolimus, J Am Soc Nephrol, 18, 236A
  13. Deutsch, 2007, Sirolimus-associated infertility: Case report and literature review of possible mechanisms, Am J Transplant, 7, 2414, 10.1111/j.1600-6143.2007.01929.x · DOI
  14. Fritsche, 2004, Testosterone concentrations and sirolimus in male renal transplant patients, Am J Transplant, 4, 130, 10.1046/j.1600-6135.2003.00279.x · DOI
  15. Huyghe, 2007, Gonadal impact of target of rapamycin inhibitors (sirolimus and everolimus) in male patients: An overview, Transpl Int, 20, 305, 10.1111/j.1432-2277.2006.00423.x · DOI · Paper page
  16. Kaczmarek, 2004, Sirolimus impairs gonadal function in heart transplant recipients, Am J Transplant, 4, 1084, 10.1111/j.1600-6143.2004.00456.x · DOI
  17. Skrzypek, 2007, Azoospermia in a renal transplant recipient during sirolimus (rapamycin) treatment, Andrologia, 39, 198, 10.1111/j.1439-0272.2007.00787.x · DOI
  18. Tondolo, 2005, Sirolimus impairs improvement of the gonadal function after renal transplantation, Am J Transplant, 5, 197, 10.1111/j.1600-6143.2005.00604.x · DOI
  19. Wullschleger, 2006, TOR signaling in growth and metabolism, Cell, 124, 471, 10.1016/j.cell.2006.01.016 · DOI · Paper page
  20. Feng, 2000, Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia, J Biol Chem, 270, 25572, 10.1074/jbc.M002218200 · DOI
  21. De Celis, 1999, Male fertility of kidney transplant patients with one to ten years of evolution using a conventional immunosuppressive regimen, Arch Androl, 42, 9, 10.1080/014850199262995 · DOI
  22. Rapamune ® FDA Pharmacology Review, approved 09 July 2004. US Food and Drug Administration, Center for Drug Evaluation and Research. NDA 21–083.
  23. Seethalakshmi, 1990, Cyclosporine: Its effects on testicular function and fertility in the prepubertal rat, J Androl, 11, 17, 10.1002/j.1939-4640.1990.tb01568.x · DOI
  24. McKay, 2006, Pregnancy in recipients of solid organs–effects on mother and child, N Engl J Med, 354, 1281, 10.1056/NEJMra050431 · DOI
  25. Kramer, 2005, Graft function, cardiovascular risk factors, and sex hormones in renal transplant recipients on an immunosuppressive regimen of everolimus, reduced dose of cyclosporine, and basiliximab, Transplant Proc, 37, 1601, 10.1016/j.transproceed.2004.09.026 · DOI
  26. Kissel, 2000, Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses, Embo J, 19, 1312, 10.1093/emboj/19.6.1312 · DOI

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Metadata

Authors
Zuber, J., Anglicheau, D., Elie, C., Bererhi, L., Timsit, M.-O., Mamzer-Bruneel, M.-F., Ciroldi, M., Martinez, F., Snanoudj, R., Hiesse, C., Kreis, H., Eustache, F., Laborde, K., Thervet, E., & Legendre, C.
Venue
American Journal of Transplantation
Publisher
Elsevier BV
Published
2008-07
Volume
8
Issue
7
Pages
1471-1479
ISSN
1600-6135
DOI
10.1111/j.1600-6143.2008.02267.x
Cited by
148
References
0
Language
en
Licence

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