Cited by 135Craniofacial Disorders and Treatmentsdental development and anomaliesCleft Lip and Palate Research

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Genetic analysis of non‐syndromic craniosynostosis

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Boyadjiev, SA, for the International Craniosynostosis Consortium·2007·Orthodontics & Craniofacial Research

DOI 10.1111/j.1601-6343.2007.00393.x

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Abstract

Structured Abstract: Authors – Simeon A. Boyadjiev Craniosynostosis is a common malformation occurring in 3–5 per 10 000 live births. Most often craniosynostosis occurs as an isolated (i.e. non‐syndromic) anomaly. Non‐syndromic craniosynostosis (NSC) is a clinically and genetically heterogeneous condition that has the characteristics of a multifactorial trait. It is believed that each sutural synostosis (e.g. sagittal, coronal) represents a different disease. Significant progress has been made in understanding the clinical and molecular aspects of monogenic syndromic craniosynostosis. However, the phenotypic characterization of NSC is incomplete and its causes remain unknown. This review summarizes the available knowledge on NSC and presents a systematic approach aimed at the identification of genetic and non‐genetic factors contributing to the risk of this common craniofacial defect.

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Authors: Boyadjiev, S., & for the International Craniosynostosis Consortium
Affiliations: University of California, Davis (US)
Corresponding author: Boyadjiev, SA
Venue: Orthodontics & Craniofacial Research
Publisher: Wiley
Published: 2007-07-21
Volume: 10
Issue: 3
Pages: 129-137
ISSN: 1601-6335 (ISSN-L)
1601-6343
DOI: 10.1111/j.1601-6343.2007.00393.x
OpenAlex: W2164204351
Cited by: 135
References: 56
Citations by year: 2026: 1 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 12 · 2021: 6 · 2020: 7 · 2019: 9 · 2018: 6 · 2017: 15 · 2016: 9 · 2015: 5 · 2014: 6 · 2013: 9 · 2012: 9
FWCI: 0.28
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Orthodontics and Craniofacial Research (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders: University of Missouri
Washington University in St. Louis
University of Washington
Johns Hopkins University
University of Oklahoma
Deutsches Krebsforschungszentrum
Children's Miracle Network Hospitals
University of Oxford
Universität zu Köln
National Institutes of Health (RR-00052)
University of California, Davis
University of California, Irvine
National Institute on Deafness and Other Communication Disorders (M01-RR00052)
National Institute of Dental and Craniofacial Research (K23 DE 00462, R03DE016342, K23DE000462, R01DE016886)
National Center for Research Resources (M01 RR-00052, RR 000 52, M01RR000052)
Topics: Health Sciences › Medicine › Surgery › Craniofacial Disorders and Treatments
Health Sciences › Dentistry › General Dentistry › dental development and anomalies
Health Sciences › Dentistry › Oral Surgery › Cleft Lip and Palate Research
Keywords: nonsyndromic craniosynostosis, cranial sutures, sagittal synostosis, coronal synostosis, genetic risk factors, craniofacial defects
MeSH terms: Cranial Sutures, Craniosynostoses, Humans, Molecular Biology, Phenotype, Risk Factors, Syndrome

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Genetic analysis of non‐syndromic craniosynostosis

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