Cited by 123Nuclear Structure and FunctionSkin and Cellular Biology ResearchGenomics and Chromatin Dynamics

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The nuclear lamina. Both a structural framework and a platform for genome organization

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Bridger, Joanna M., Foeger, Nicole, Kill, Ian R., Herrmann, Harald·2007·The FEBS Journal

DOI 10.1111/j.1742-4658.2007.05694.x

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Abstract

The inner face of the nuclear envelope of metazoan cells is covered by a thin lamina consisting of a one-layered network of intermediate filaments interconnecting with a complex set of transmembrane proteins and chromatin associating factors. The constituent proteins, the lamins, have recently gained tremendous recognition, because mutations in the lamin A gene, LMNA, are the cause of a complex group of at least 10 different diseases in human, including the Hutchinson-Gilford progeria syndrome. The analysis of these disease entities has made it clear that besides cytoskeletal functions, the lamina has an important role in the "behaviour" of the genome and is, probably as a consequence of this function, intimately involved in cell fate decisions. Furthermore, these functions are related to the involvement of lamins in organizing the position and functional state of interphase chromosomes as well as to the occurrence of lamins and lamina-associated proteins within the nucleoplasm. However, the structural features of these lamins and the nature of the factors that assist them in genome organization present an exciting challenge to modern biochemistry and cell biology.

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Authors: Bridger, J. M., Foeger, N., Kill, I. R., & Herrmann, H.
Affiliations: Brunel University of London (GB)
Vienna Biocenter (AT)
German Cancer Research Center (DE)
ORCID: Bridger, Joanna M.
Foeger, Nicole
Herrmann, Harald
Venue: The FEBS Journal
Publisher: Wiley
Published: 2007-02-28
Volume: 274
Issue: 6
Pages: 1354-1361
ISSN: 1742-464X (ISSN-L)
1742-4658
DOI: 10.1111/j.1742-4658.2007.05694.x
OpenAlex: W1482103235
Cited by: 123
References: 69
Citations by year: 2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 4 · 2013: 7 · 2012: 8
FWCI: 1.36
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Journal (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsches Krebsforschungszentrum
European Commission
Austrian Science Fund
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: nuclear lamina, nuclear lamins, lamin A/C, Hutchinson-Gilford progeria syndrome, nuclear envelope, intermediate filaments, chromatin proteins, genome organization, interphase chromosomes, cell fate determination
MeSH terms: Protein Conformation, Proteins, Genome, Nuclear Lamina

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The nuclear lamina. Both a structural framework and a platform for genome organization

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