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Drug‐resistant malaria − an insight
Open accessAbstract
Despite intensive research extending back to the 1930s, when the first synthetic antimalarial drugs made their appearance, the repertoire of clinically licensed formulations remains very limited. Moreover, widespread and increasing resistance to these drugs contributes enormously to the difficulties in controlling malaria, posing considerable intellectual, technical and humanitarian challenges. A detailed understanding of the molecular mechanisms underlying resistance to these agents is emerging that should permit new drugs to be rationally developed and older ones to be engineered to regain their efficacy. This review summarizes recent progress in analysing the causes of resistance to the major antimalarial drugs and its spread.
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Yeast Model Uncovers Dual Roles of Mitochondria in the Action of Artemisinin
Li, W., Mo, W., Shen, D., Sun, L., Wang, J., Lu, S., Gitschier, J. M., & Zhou, B. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010036 · Cited by 304
Cited by
Plasmodium—a brief introduction to the parasites causing human malaria and their basic biology
Sato, S. (2021) · Journal of Physiological Anthropology · doi:10.1186/s40101-020-00251-9 · Cited by 404
Van Leeuwen, T., Vanholme, B., Van Pottelberge, S., Van Nieuwenhuyse, P., Nauen, R., Tirry, L., & Denholm, I. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802224105 · Cited by 279
Metadata
- Authors
- Hyde, J. E.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2007-08-30
- Volume
- 274
- Issue
- 18
- Pages
- 4688-4698
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W1603093745
- Cited by
- 239
- References
- 1
- FWCI
- 13.77
- Type
- journal article
- Language
- en
- Open access
- green
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