The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
What’s in a covalent bond?: On the role and formation of covalently bound flavin cofactors
Open accessAbstract
Many enzymes use one or more cofactors, such as biotin, heme, or flavin. These cofactors may be bound to the enzyme in a noncovalent or covalent manner. Although most flavoproteins contain a noncovalently bound flavin cofactor (FMN or FAD), a large number have these cofactors covalently linked to the polypeptide chain. Most covalent flavin–protein linkages involve a single cofactor attachment via a histidyl, tyrosyl, cysteinyl or threonyl linkage. However, some flavoproteins contain a flavin that is tethered to two amino acids. In the last decade, many studies have focused on elucidating the mechanism(s) of covalent flavin incorporation (flavinylation) and the possible role(s) of covalent protein–flavin bonds. These endeavors have revealed that covalent flavinylation is a post‐translational and self‐catalytic process. This review presents an overview of the known types of covalent flavin bonds and the proposed mechanisms and roles of covalent flavinylation.
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Cites
Function and Structure of Complex II of the Respiratory Chain
Cecchini, G. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161700 · Cited by 556
Cited by
SDH5 , a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma
Hao, H.-X., Khalimonchuk, O., Schraders, M., Dephoure, N., Bayley, J.-P., Kunst, H., Devilee, P., Cremers, C. W. R. J., Schiffman, J. D., Bentz, B. G., et al. (2009) · Science · doi:10.1126/science.1175689 · Cited by 702
Tong, Y., Kaya, S. G., Russo, S., Rozeboom, H. J., Wijma, H. J., & Fraaije, M. W. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c12009 · Cited by 24
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Metadata
- Authors
- Heuts, D. P. H. M., Scrutton, N. S., McIntire, W. S., & Fraaije, M. W.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2009-06-11
- Volume
- 276
- Issue
- 13
- Pages
- 3405-3427
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W1882140875
- Cited by
- 184
- References
- 1
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Heuts, D. P. H. M., Scrutton, N. S., McIntire, W. S., & Fraaije, M. W. (2009). What’s in a covalent bond?: On the role and formation of covalently bound flavin cofactors. The FEBS Journal. https://doi.org/10.1111/j.1742-4658.2009.07053.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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