The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Amyloid oligomers: formation and toxicity of Aβ oligomers
Open accessAbstract
Alzheimer’s disease (AD) is an age‐related, progressive degenerative disorder that is characterized by synapse and neuron loss in the brain and the accumulation of protein‐containing deposits (referred to as ‘senile plaques’) and neurofibrillary tangles. Insoluble amyloid β‐peptide (Aβ) fibrillar aggregates found in extracellular plaques have long been thought to cause the neurodegenerative cascades of AD. However, accumulating evidence suggests that prefibrillar soluble Aβ oligomers induce AD‐related synaptic dysfunction. The size of Aβ oligomers is distributed over a wide molecular weight range (from < 10 kDa to > 100 kDa), with structural polymorphism in Aβ oligomers of similar sizes. Recent studies have demonstrated that Aβ can accumulate in living cells, as well as in extracellular spaces. This review summarizes current research on Aβ oligomers, focusing on their structures and toxicity mechanism. We also discuss possible formation mechanisms of intracellular and extracellular Aβ oligomers.
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2 retracted
RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
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RetractedAlzheimer's disease: the amyloid cascade hypothesis
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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
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Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins
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Cited by
Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight
Bhat, A. H., Dar, K. B., Anees, S., Zargar, M. A., Masood, A., Sofi, M. A., & Ganie, S. A. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.07.025 · Cited by 928
Morris, M., Maeda, S., Vossel, K., & Mucke, L. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.009 · Cited by 899
Amyloid toxicity in Alzheimer’s disease
Reiss, A. B., Arain, H. A., Stecker, M. M., Siegart, N. M., & Kasselman, L. J. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0063 · Cited by 447
Plaque formation and the intraneuronal accumulation of β‐amyloid in Alzheimer's disease
Takahashi, R. H., Nagao, T., & Gouras, G. K. (2017) · Pathology International · doi:10.1111/pin.12520 · Cited by 346
Oligomeric Intermediates in Amyloid Formation: Structure Determination and Mechanisms of Toxicity
Fändrich, M. (2012) · Journal of Molecular Biology · doi:10.1016/j.jmb.2012.01.006 · Cited by 340
Metadata
- Authors
- Sakono, M., & Zako, T.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2010-02-24
- Volume
- 277
- Issue
- 6
- Pages
- 1348-1358
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2170709967
- Cited by
- 605
- References
- 32
- FWCI
- 25.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
