MicroRNAs and cardiovascular diseases
Open accessAbstract
MicroRNAs (miRNAs) are a class of small noncoding RNAs that have gained status as important regulators of gene expression. Recent studies have demonstrated that miRNAs are aberrantly expressed in the cardiovascular system under some pathological conditions. Gain- and loss-of-function studies using in vitro and in vivo models have revealed distinct roles for specific miRNAs in cardiovascular development and physiological function. The implications of miRNAs in cardiovascular disease have recently been recognized, representing the most rapidly evolving research field. In the present minireview, the current relevant findings on the role of miRNAs in cardiac diseases are updated and the target genes of these miRNAs are summarized.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Successful expansion of ribosome biogenesis in skeletal muscle likely requires coordinated adaptation at transcription and at RNA processing and maturation guided by small RNAs.
“Consequently, while direct human transcriptomic data tracing snoRNA dynamics during resistance training remain limited, the successful expansion of ribosome biogenesis in skeletal muscle likely requires coordinated adaptation not only at the level of transcription but also at the level of RNA processing and maturation guided by these small RNAs [200,201].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [201]
The Introduction discusses how microRNAs regulate gene expression, and the Cardiac hypertrophy section discusses transcriptional regulation of microRNAs in the heart. Neither addresses snoRNA-guided RNA processing and maturation or the expansion of ribosome biogenesis in skeletal muscle. Searches for those terms returned no passage supporting the attributed claim; page numbers were unavailable in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 147 · Cited by 169
- Authors
- Ono, K., Kuwabara, Y., & Han, J.
- Affiliations
- Scripps Research Institute (US)
- Kyoto University (JP)
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2011-03-30
- Volume
- 278
- Issue
- 10
- Pages
- 1619-1633
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- PMC
- PMC3087823
- OpenAlex
- W2167919777
- Cited by
- 169
- References
- 147
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 13 · 2020: 9 · 2019: 11 · 2018: 12 · 2017: 18 · 2016: 17 · 2015: 16 · 2014: 20 · 2013: 17 · 2012: 12
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Journal (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Japan Society for the Promotion of Science (23390211)
- National Institute of Allergy and Infectious Diseases (R01AI068896, AI068896)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- microRNA, cardiovascular disease, heart disease, gene expression regulation, non-coding RNA, miRNA target genes, cardiovascular development
- MeSH terms
- Animals, Arrhythmias, Cardiac, Cardiovascular Diseases, Fibrosis, Heart, Heart Diseases, Cardiomegaly, Heart Failure, Humans, Myocardial Infarction, Myocardium, Proteins, RNA-Binding Proteins, Neovascularization, Physiologic, Metabolic Syndrome, MicroRNAs, Ribonuclease III, Mice, DEAD-box RNA Helicases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
