The DOI matches its Crossref record.
Protein-Losing Enteropathy after Fontan Operation
Abstract
Protein-losing enteropathy (PLE) is a poorly understood and enigmatic disease process affecting patients with single ventricle after Fontan operation. In those afflicted, PLE after Fontan operation results in significant morbidity and mortality. The pathophysiology of the disease is unknown; however, a proposed mechanism incorporates a combination of phenomena including: (1) altered hemodynamics, specifically low cardiac output; (2) increased mesenteric vascular resistance; (3) systemic inflammation; and (4) altered enterocyte basal membrane glycosaminoglycan make-up. A paradigm for the clinical management of PLE after Fontan operation is proposed.
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Citations
Cited by
The Fontan circulation after 45 years: update in physiology
Gewillig, M., & Brown, S. C. (2016) · Heart · doi:10.1136/heartjnl-2015-307467 · Cited by 538
Di Salvo, G., Miller, O., Babu Narayan, S., Li, W., Budts, W., Valsangiacomo Buechel, E. R., Frigiola, A., van den Bosch, A. E., Bonello, B., Mertens, L., et al. (2018) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jey102 · Cited by 110
Metadata
- Authors
- Rychik, J.
- Venue
- Congenital Heart Disease
- Published
- 2007-09
- Volume
- 2
- Issue
- 5
- Pages
- 288-300
- ISSN
- 1747-079X (ISSN-L)
- 1747-0803
- OpenAlex
- W1976809330
- Cited by
- 190
- References
- 0
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rychik, J. (2007). Protein-Losing Enteropathy after Fontan Operation. Congenital Heart Disease. https://doi.org/10.1111/j.1747-0803.2007.00116.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
