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Evidence indicating trophic importance of IGF‐1 in regenerating peripheral nerves
Abstract
The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm‐C/insulin‐like growth factor I/IGF‐I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF‐I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF‐synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF‐I exerts important growth supporting effects on regenerating peripheral nerves.
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Citations
Cited by
The cellular and molecular basis of peripheral nerve regeneration
Fu, S. Y., & Gordon, T. (1997) · Molecular Neurobiology · doi:10.1007/bf02740621 · Cited by 1,202
Lundborg, G. (2000) · The Journal of Hand Surgery · doi:10.1053/jhsu.2000.4165 · Cited by 656
Self-citationMotor axons preferentially reinnervate motor pathways
Brushart, T. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-06-02730.1993 · Cited by 395
Insulin-like growth factor I (IGF-I) stimulates regeneration of the rat sciatic nerve
Kanje, M., Skottner, A., Sjo¨berg, J., & Lundborg, G. (1989) · Brain Research · doi:10.1016/0006-8993(89)90531-3 · Cited by 277
Self-citationGrowth Factors and Wound Healing
Steenfos, H. H. (1994) · Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery · doi:10.3109/02844319409071186 · Cited by 192
Metadata
- Authors
- HANSSON, H. A., DAHLIN, L. B., DANIELSEN, N., FRYKLUND, L., NACHEMSON, A. K., POLLERYD, P., ROZELL, B., SKOTTNER, A., STEMME, S., & LUNDBORG, G.
- Venue
- Acta Physiologica Scandinavica
- Publisher
- Wiley
- Published
- 1986-04
- Volume
- 126
- Issue
- 4
- Pages
- 609-614
- ISSN
- 0001-6772 (ISSN-L)
- 1365-201X
- OpenAlex
- W2078544533
- Cited by
- 222
- References
- 0
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- HANSSON, H. A., DAHLIN, L. B., DANIELSEN, N., FRYKLUND, L., NACHEMSON, A. K., POLLERYD, P., ROZELL, B., SKOTTNER, A., STEMME, S., & LUNDBORG, G. (1986). Evidence indicating trophic importance of IGF‐1 in regenerating peripheral nerves. Acta Physiologica Scandinavica. https://doi.org/10.1111/j.1748-1716.1986.tb07862.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
