Chronic nicotine treatment partly protects against the 1‐methyl‐4‐phenyl‐2, 3, 6‐tetrahydropyridine‐induced degeneration of nigrostriatal dopamine neurons in the black mouse
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Nicotine protects rodent DA neurons against toxin-induced cell loss.
“Nicotine protects rodent DA neurons agonist toxin-induced cell loss (21–24), but these neuroprotective effects are absent in α4 nAChR knockout (KO) mice (22).”
From Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery (2009) · cites this paper as [23]
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References 8 · Cited by 56
- Authors
- JANSON, A. M., FUXE, K., SUNDSTRÖM, E., AGNATI, L. F., & GOLDSTEIN, M.
- Affiliations
- Karolinska Institutet (SE)
- University of Modena and Reggio Emilia (IT)
- NYU Langone Health (US)
- Corresponding author
- JANSON, A. M.
- ORCID
- SUNDSTRÖM, E.
- Venue
- Acta Physiologica Scandinavica
- Publisher
- Wiley
- Published
- 1988-04
- Volume
- 132
- Issue
- 4
- Pages
- 589-591
- ISSN
- 0001-6772 (ISSN-L)
- 1365-201X
- OpenAlex
- W2084285811
- Cited by
- 56
- References
- 8
- Citations by year
- 2020: 1 · 2015: 1 · 2013: 2 · 2012: 1
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Physiologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- nicotine, MPTP-induced neurotoxicity, nigrostriatal dopaminergic neurons, neuroprotection, Parkinson's disease model
- MeSH terms
- Animals, Corpus Striatum, Mice, Inbred C57BL, Nerve Degeneration, Nicotine, Pyridines, Receptors, Dopamine, Substantia Nigra, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Mice
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