The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Ontogeny of the Serotonergic System in the Rat: Serotonin as a Developmental Signala
Abstract
The serotonergic system is an early forming component of the CNS circuitry, beginning its development on gestational days 11-12 in the rat. Owing to its early presence in the embryonic nervous system, 5-HT has been proposed to act as a developmental signal for receptive cells. In vivo and in vitro evidence that 5-HT can influence both biochemical and morphological differentiation of raphe neurons and receptive target cells suggests that this neurotransmitter may have an organizing function in the developing nervous system which involves effects on neurite outgrowth and other aspects of neuronal differentiation, including synaptogenesis. Such functions may be mediated by a variety of 5-HT receptors located on both neuronal and non-neuronal cells. The apparent function of 5-HT as a differentiation signal in the developing nervous system raises important issues regarding the use of psychoactive serotonergic drugs by pregnant women, since these drugs may act as neural teratogens in the unborn child.
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Citations
Cites
Neurotransmitters as morphogens
Lauder, J. M. (1988) · Progress in Brain Research · doi:10.1016/s0079-6123(08)60516-6 · Cited by 257
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Cited by
Rice, D., & Barone, S. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108s3511 · Cited by 2,944
Adolescent cortical development: A critical period of vulnerability for addiction
Crews, F., He, J., & Hodge, C. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.12.001 · Cited by 1,091
Brezun, J. M., & Daszuta, A. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00693-9 · Cited by 549
Serotonin and brain development: role in human developmental diseases
Whitaker-Azmitia, P. M. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00615-3 · Cited by 506
Serotonin as a developmental signal
Whitaker-Azmitia, P. M., Druse, M., Walker, P., & Lauder, J. M. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00071-x · Cited by 356
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Metadata
- Authors
- LAUDER, J. M.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 1990-10
- Volume
- 600
- Issue
- 1
- Pages
- 297-313
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1996340413
- Cited by
- 405
- References
- 1
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- LAUDER, J. M. (1990). Ontogeny of the Serotonergic System in the Rat: Serotonin as a Developmental Signala. Annals of the New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.1990.tb16891.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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