Clinical Features Associated with Glucocorticoid Receptor Polymorphisms

Manenschijn, Laura; van den Akker, Erica L. T.; Lamberts, Steven W. J.; van Rossum, Elisabeth F. C.

doi:10.1111/j.1749-6632.2009.05013.x

Clinical Features Associated with Glucocorticoid Receptor Polymorphisms

The glucocorticoid receptor (GR) is crucial for the effects of glucocorticoids (GCs). Several polymorphisms of the GR are associated with altered sensitivity to GCs. For the ER22/23EK polymorphism, a relative GC resistance has been demonstrated. In vivo , this was suggested by a smaller response …