The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
The progression of pathology in Parkinson's disease
Abstract
To identify the progression of pathology over the entire course of Parkinson's disease, we longitudinally followed a clinical cohort to autopsy and identified three clinicopathological phenotypes that progress at different rates. Typical Parkinson's disease has an initial rapid loss of midbrain dopamine neurons with a slow progression of Lewy body infiltration into the brain (over decades). Dementia intervenes late when Lewy bodies invade the neocortex. Older onset patients (> 70 years old) dement earlier and have much shorter disease durations. Paradoxically, they have far more α‐synuclein‐containing Lewy bodies throughout the brain, and many also have additional age‐related plaque pathology. In contrast, dementia with Lewy bodies has the shortest disease course, with substantive amounts of Lewy bodies and Alzheimer‐type pathologies infiltrating the brain. These data suggest that two age‐related factors influence pathological progression in Parkinson's disease—the age at symptom onset and the degree and type of age‐related Alzheimer‐type pathology.
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Cites
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
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Self-citationAGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY
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Diagnostic Criteria for Parkinson Disease
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Cited by
Poewe, W., Seppi, K., Tanner, C. M., Halliday, G. M., Brundin, P., Volkmann, J., Schrag, A.-E., & Lang, A. E. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.13 · Cited by 5,415
Self-citationReduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson’s disease
Murphy, K. E., Gysbers, A. M., Abbott, S. K., Tayebi, N., Kim, W. S., Sidransky, E., Cooper, A., Garner, B., & Halliday, G. M. (2014) · Brain · doi:10.1093/brain/awt367 · Cited by 475
Self-citationMcCann, H., Stevens, C. H., Cartwright, H., & Halliday, G. M. (2014) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(13)70017-8 · Cited by 364
Self-citationAre synucleinopathies prion-like disorders?
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BAG2 structure, function and involvement in disease
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Metadata
- Authors
- Halliday, G. M., & McCann, H.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2010-01
- Volume
- 1184
- Issue
- 1
- Pages
- 188-195
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2147411610
- Cited by
- 299
- References
- 61
- FWCI
- 12.38
- Type
- journal article
- Language
- en
- Open access
- closed
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