The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
NF‐κB and innate immunity in ischemic stroke
Open accessAbstract
Acute cerebral ischemia elicits an innate immune response that leads to a cascade of events that culminates in necrotic death of neurons and injury to their supportive structures in the neurovascular unit. Indeed, clinical studies have shown a close relationship between elevated levels of inflammatory markers and the risk for ischemic stroke. However, the signaling pathways that link these events are not well understood. A central regulator of inflammatory response is the transcription factor, nuclear factor‐kappa B (NF‐κB). The activation of NF‐κB is required for the transcriptional induction of many proinflammatory mediators involved in innate immunity, such as cellular adhesion molecules, cytokines, and growth factors. Therefore, factors that modulate the activity of NF‐κB could potentially regulate inflammatory processes in ischemic stroke. Here, we review the relationship between NF‐κB and ischemic stroke, its role in the neurovascular unit, and discuss some animal models that suggest that this relationship is causal.
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NF-κB is activated and promotes cell death in focal cerebral ischemia
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TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2
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Cited by
Neuroinflammation: friend and foe for ischemic stroke
Jayaraj, R. L., Azimullah, S., Beiram, R., Jalal, F. Y., & Rosenberg, G. A. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1516-2 · Cited by 1,428
Current advances in ischemic stroke research and therapies
Barthels, D., & Das, H. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.09.012 · Cited by 709
Sivandzade, F., Prasad, S., Bhalerao, A., & Cucullo, L. (2019) · Redox Biology · doi:10.1016/j.redox.2018.11.017 · Cited by 639
NLRP3 inflammasome in neurological diseases, from functions to therapies
Song, L., Pei, L., Yao, S., Wu, Y., & Shang, Y. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00063 · Cited by 467
Inflammation in Glaucoma: From the back to the front of the eye, and beyond
Baudouin, C., Kolko, M., Melik-Parsadaniantz, S., & Messmer, E. M. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100916 · Cited by 454
Metadata
- Authors
- Harari, O. A., & Liao, J. K.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2010-10
- Volume
- 1207
- Issue
- 1
- Pages
- 32-40
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1534620902
- Cited by
- 311
- References
- 46
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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