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Glioblastoma with Adipocyte‐Like Tumor Cell Differentiation—Histological and Molecular Features of a Rare Differentiation Pattern
Open accessAbstract
We report on three adult patients with primary glioblastomas showing prominent adipocytic (lipomatous) differentiation, hence referred to as “glioblastomas with adipocyte‐like tumor cell differentiation.” Histologically, the tumors demonstrated typical features of glioblastoma but additionally contained areas consisting of glial fibrillary acidic protein (GFAP)‐positive astrocytic tumor cells resembling adipocytes, that is, containing large intracellular lipid vacuoles. Comparative genomic hybridization (CGH) and focused molecular genetic analyses demonstrated gains of chromosomes 7, losses of chromosomes 9 and 10, as well as homozygous deletion of p14 ARF in one of the tumors. The second tumor showed gains of chromosomes 3, 4, 8q and 12 as well as losses of chromosomes 10, 13, 15q, 19 and 22. In addition, this tumor carried homozygous deletions of CDKN2A and p14 ARF as well as point mutations in the TP53 and PTEN genes. The third tumor also had a mutation in the PTEN gene. None of the tumors demonstrated EGFR, CDK4 or MDM2 amplification. Taken together, our results define a rare glioblastoma differentiation pattern and indicate that glioblastomas with adipocyte‐like tumor cell differentiation share common molecular genetic features with other primary glioblastomas.
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“ARF deletion is correlated with overexpression of tectonic family member 1 (TCTN1), a protein involved in a diverse range of cellular processes, including promotion of GBM cell proliferation.”
From The p53 Pathway in Glioblastoma (2018) · cites this paper as [37]
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Metadata
- Authors
- Rickert, C. H., Riemenschneider, M. J., Schachenmayr, W., Richter, H., Bockhorn, J., Reifenberger, G., & Paulus, W.
- Affiliations
- Royal Children's Hospital (AU)
- Heinrich Heine University Düsseldorf (DE)
- Universitätsklinikum Gießen und Marburg (DE)
- University Hospital Ulm (DE)
- Bayreuth Medical Center (DE)
- University Hospital Münster (DE)
- Venue
- Brain Pathology
- Publisher
- Wiley
- Published
- 2009-06-10
- Volume
- 19
- Issue
- 3
- Pages
- 431-438
- ISSN
- 1015-6305 (ISSN-L)
- 1750-3639
- PMC
- PMC8094827
- OpenAlex
- W2043449331
- Cited by
- 23
- References
- 39
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Keywords
- glioblastoma, lipomatous differentiation, glial fibrillary acidic protein, chromosome gains and losses, CDKN2A deletion, TP53 mutation, PTEN mutation, molecular genetic features
- MeSH terms
- Aged, Brain Neoplasms, Cell Differentiation, DNA Mutational Analysis, Female, Glioblastoma, Humans, Immunohistochemistry, Male, Middle Aged, Polymerase Chain Reaction, Adipocytes, Polymorphism, Single-Stranded Conformational, Microscopy, Electron, Transmission, Comparative Genomic Hybridization
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