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COMPARATIVE STUDY OF OXIDATION OF NUCLEIC ACID COMPONENTS BY HYDROXYL RADICALS, SINGLET OXYGEN AND SUPEROXIDE ANION RADICALS
Abstract
Abstract— Superoxide radicals, singlet oxygen and hydroxyl radicals are individually or in combination involved in radiation or photochemical processes and in various enzymatic reactions. The reactivity and the mechanism of reaction of these oxygen species with some biologically significant DNA components were investigated through the characterization of the final oxidation products. Superoxide radicals appear to be unreactive with purine and pyrimidine 2'‐deoxyribonucleosides. However, the autoxidation reaction of 6‐hydroxydopamine leads to extensive degradation of thymine through the intermediary of hydroxyl radicals. Chemically and microwave‐discharge generated singlet oxygen oxidation is specific to 2'‐deoxyguanosine. The main oxidized products of these reactions were also characterized as well as an as yet unidentified nucleoside in the methylene‐blue photooxydation of 2‐deoxyguanosine. These results, in addition to specific deuterium effect experiments, lend support to the involvment of singlet oxygen (type II mechanism) in the methylene‐blue photosentization. No singlet oxygen effect was observed in aqueous irradiated system.
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Citations
Cited by
Direct and indirect effects of UV radiation on DNA and its components
Ravanat, J.-L., Douki, T., & Cadet, J. (2001) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(01)00206-8 · Cited by 980
Self-citationPhotocleavage of Nucleic Acids
Armitage, B. (1998) · Chemical Reviews · doi:10.1021/cr960428+ · Cited by 688
Singlet Molecular Oxygen Reactions with Nucleic Acids, Lipids, and Proteins
Di Mascio, P., Martinez, G. R., Miyamoto, S., Ronsein, G. E., Medeiros, M. H. G., & Cadet, J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00554 · Cited by 659
Self-citationRadiation-induced DNA Damage and Its Repair
Téoule, R. (1987) · International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine · doi:10.1080/09553008414552111 · Cited by 406
Carcinogen-mediated oxidant formation and oxidative DNA damage
Frenkel, K. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90047-4 · Cited by 379
Metadata
- Authors
- Cadet, J., & Teoule, R.
- Venue
- Photochemistry and Photobiology
- Publisher
- Wiley
- Published
- 1978-10
- Volume
- 28
- Issue
- 4-5
- Pages
- 661-665
- ISSN
- 0031-8655 (ISSN-L)
- 1751-1097
- OpenAlex
- W2087353839
- Cited by
- 197
- References
- 0
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: COMPARATIVE STUDY OF OXIDATION OF NUCLEIC ACID COMPONENTS BY HYDROXYL RADICALS, SINGLET OXYGEN AND SUPEROXIDE ANION RADICALS. https://app.cochat.ai/papers/10.1111/j.1751-1097.1978.tb06991.x
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- Cadet, J., & Teoule, R. (1978). COMPARATIVE STUDY OF OXIDATION OF NUCLEIC ACID COMPONENTS BY HYDROXYL RADICALS, SINGLET OXYGEN AND SUPEROXIDE ANION RADICALS. Photochemistry and Photobiology. https://doi.org/10.1111/j.1751-1097.1978.tb06991.x
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